Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 18/20 | 0.60 |
| ▸ | FLT3 | P36888 | 11/20 | 0.60 |
| ▸ | KIT | P10721 | 10/20 | 0.60 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.43 |
| ▸ | CSF1R | P07333 | 3/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.43 |
| ▸ | CDK8 | P49336 | 2/20 | 0.43 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.43 |
| ▸ | FLT1 | P17948 | 2/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | LTK | P29376 | 1/20 | 0.43 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 2/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | LYN | P07948 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27657309 | 0.90 | KDR (0.57) | KDRFLT3KITPDGFRBCSF1R | |
| SCHEMBL27657548 | 0.88 | KDR (0.48) | KDRFLT3KITPDGFRBCSF1R | |
| SCHEMBL3359876 | 0.83 | KDR (0.61) | KDRFLT3KITPDGFRBCSF1R | |
| SCHEMBL3360963 | 0.83 | KDR (0.59) | KDRFLT3KITPDGFRBCSF1R | |
| SCHEMBL421024 | 0.82 | KDR (0.84) | KDRFLT3KITPDGFRBCSF1R | |
| SCHEMBL13372713 | 0.81 | KDR (0.52) | KDRFLT3KITPDGFRBCSF1R | |
| SCHEMBL13372721 | 0.80 | KDR (0.57) | KDRFLT3KITPDGFRBCSF1R | |
| SCHEMBL27657317 | 0.80 | KDR (0.57) | KDRFLT3KITPDGFRBCSF1R | |
| SCHEMBL27657310 | 0.80 | KDR (0.59) | KDRFLT3KITPDGFRBCSF1R | |
| SCHEMBL27636401 | 0.80 | KDR (0.55) | KDRFLT3KITPDGFRBCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2246333-A1 | Indazole, benzisoxazole, and benzisothiazole kinase inhibitors | Abbott Laboratories (US) | 2010-11-03 | — | — | EP | disclosed |