Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.70 |
| ▸ | FLT1 | P17948 | 13/20 | 0.67 |
| ▸ | RAF1 | P04049 | 1/20 | 0.66 |
| ▸ | LCK | P06239 | 1/20 | 0.66 |
| ▸ | RET | P07949 | 1/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.66 |
| ▸ | KIT | P10721 | 1/20 | 0.66 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.66 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.66 |
| ▸ | NAMPT | P43490 | 4/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3361283 | 0.85 | KDR (0.63) | KDRFLT1RAF1LCKRET | |
| SCHEMBL3363670 | 0.84 | BRAF (0.67) | KDRFLT1RAF1LCKRET | |
| SCHEMBL429443 | 0.82 | KDR (1.00) | KDRFLT1KITNAMPT | |
| SCHEMBL426401 | 0.82 | KDR (0.78) | KDRFLT1RAF1LCKRET | |
| SCHEMBL4980248 | 0.81 | KDR (0.74) | KDRFLT1KITNAMPT | |
| SCHEMBL4018411 | 0.80 | L3MBTL1 (0.58) | KDRFLT1RAF1LCKRET | |
| Osi-930 SCHEMBL29352171 | 0.80 | KDR (1.00) | KDRFLT1RAF1LCKRET | |
| Osi-930 SCHEMBL633719 | 0.80 | KDR (1.00) | KDRFLT1RAF1LCKRET | |
| SCHEMBL1819542 | 0.78 | KDR (0.67) | KDRFLT1RAF1LCKRET | |
| SCHEMBL633813 | 0.78 | KDR (0.75) | KDRFLT1RAF1LCKRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010088000-A2 | ANTIFIBROTIC COMPOUNDS AND USES THEREOF | ANGION BIOMEDICA CORP. (US) | 2010-08-05 | — | — | WO | claimed |
| WO-2010088000-A2 | ANTIFIBROTIC COMPOUNDS AND USES THEREOF | ANGION BIOMEDICA CORP. (US) | 2010-08-05 | — | — | WO | disclosed |