Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 2/20 | 0.49 |
| ▸ | GRM5 | P41594 | 4/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.32 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 2/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.30 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3359643 | 0.87 | GSK3B (0.36) | ZAP70GRM5P2RX3IRAK4TBK1 | |
| SCHEMBL3360220 | 0.83 | MAPT (0.43) | ZAP70SYKCDK2 | |
| SCHEMBL1047243 | 0.76 | ZAP70 (0.80) | ZAP70GRM5 | |
| SCHEMBL3357115 | 0.67 | JAK2 (0.43) | ZAP70IRAK4TBK1SYKSRC | |
| SCHEMBL3360206 | 0.67 | ZAP70 (0.42) | ZAP70SYK | |
| SCHEMBL3359732 | 0.66 | SYK (0.45) | ZAP70SYK | |
| SCHEMBL3359744 | 0.65 | CYP1A2 (0.53) | ZAP70SRCLRRK2 | |
| SCHEMBL3359868 | 0.65 | JAK2 (0.46) | ZAP70IRAK4TBK1SYKSRC | |
| SCHEMBL3395819 | 0.64 | MAPK10 (0.47) | ZAP70SYK | |
| SCHEMBL3362734 | 0.64 | ULK1 (0.41) | ZAP70SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |