Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | CDC7 | O00311 | 2/20 | 0.50 |
| ▸ | SCN4A | P35499 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | TAS2R38 | P59533 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL916879 | 0.76 | POLB (0.44) | ALDH1A1HPGDNOTUMPOLBNPC1 | |
| SCHEMBL20510086 | 0.75 | KDM4E (0.50) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL30205335 | 0.75 | MAP2K1 (0.57) | KDM4EALDH1A1HPGDSCN4AMAPT | |
| SCHEMBL13977309 | 0.71 | CDC7 (0.57) | KDM4ECDC7MAPTNPC1RAB9A | |
| SCHEMBL6196932 | 0.71 | NOTUM (0.56) | ALDH1A1HPGDNOTUMMAPTNPY5R | |
| SCHEMBL1536003 | 0.70 | NOTUM (0.56) | KDM4EALDH1A1HPGDHSD17B10NOTUM | |
| SCHEMBL6508629 | 0.70 | HPGD (0.49) | KDM4EALDH1A1HPGDHSD17B10CDC7 | |
| Biphenyl SCHEMBL21523336 | 0.70 | SCN4A (0.54) | KDM4EALDH1A1HPGDNOTUMPOLB | |
| SCHEMBL28544732 | 0.69 | KDM4E (1.00) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL15335986 | 0.69 | KDM4E (0.51) | KDM4EALDH1A1HPGDHSD17B10CDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115710251-A | Myeloid differentiation factor 88 inhibitor and preparation method and application thereof | 杭州医学院 | 2023-02-24 | — | — | CN | claimed |
| WO-2026017114-A1 | USE OF PHENYLPYRIMIDINONE COMPOUND | 苏州旺山旺水生物医药股份有限公司 | 2026-01-22 | — | — | WO | disclosed |
| CN-115710251-B | Medullary differentiation factor 88 inhibitor and preparation method and application thereof | 杭州医学院 | 2024-05-28 | — | — | CN | disclosed |
| CN-117157285-A | Pharmaceutical compounds as ubiquitin-specific protease 19 (USP 19) inhibitors | 阿尔麦克探索有限公司 | 2023-12-01 | — | — | CN | disclosed |
| CN-115710251-A | Myeloid differentiation factor 88 inhibitor and preparation method and application thereof | 杭州医学院 | 2023-02-24 | — | — | CN | disclosed |
| US-8242129-B2 | 6-phenylpyrimidinones as PIM modulators | EXELIXIS, INC. (US) | 2012-08-14 | — | — | US | disclosed |
| CN-102317266-A | 6-phenylpyrimidinones as PIM modulators | EXELIXIS INC | 2012-01-11 | — | — | CN | disclosed |
| US-20100135954-A1 | 6-Phenylpyrimidinones as PIM Modulators | EXELIXIS, INC. (US) | 2010-06-03 | — | — | US | disclosed |
| EP-0863882-B1 | AMINO SUBSTITUTED PYRIMIDINES AND TRIAZINES | JANSSEN PHARMACEUTICA NV (BE) | 2002-02-06 | — | — | EP | disclosed |
| US-6288060-B1 | CORTICOTROPIN RELEASING FACTOR ANTAGONISTS; ANXIOLYTIC, ANTIDEPRESSANT, ANTIINFLAMMATORY AGENTS; EATING DISORDERS | NEUROCRINE BIOSCIENCES, INC. | 2001-09-11 | — | — | US | disclosed |
| EP-0863882-A1 | AMINO SUBSTITUTED PYRIMIDINES AND TRIAZINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997014684-A1 | AMINO SUBSTITUTED PYRIMIDINES AND TRIAZINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-04-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100135954-A1 | 6-Phenylpyrimidinones as PIM Modulators | PIM1, PIM2, PIM3 | KDM4E 672/4885ALDH1A1 851/4885HPGD 2939/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.