Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 7/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 7/20 | 0.37 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1238022 | 0.81 | — | — | |
| Hydrochloric Acid SCHEMBL9956684 | 0.79 | POLB (0.41) | POLBATAD2ALDH1A1MEN1KMT2A | |
| SCHEMBL30693692 | 0.79 | NOTUM (0.56) | PDE3BPDE3AGPR84NOTUMAURKA | |
| Hydrochloric Acid SCHEMBL9958494 | 0.79 | POLB (0.41) | POLBATAD2ALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL1238060 | 0.79 | POLB (0.41) | POLBATAD2ALDH1A1MEN1KMT2A | |
| SCHEMBL20510086 | 0.77 | KDM4E (0.50) | POLBNPC1RAB9AALDH1A1TP53 | |
| SCHEMBL2162436 | 0.77 | KDM4E (0.42) | POLBNPC1RAB9AALDH1A1TP53 | |
| SCHEMBL3361201 | 0.76 | KDM4E (0.53) | POLBNPC1RAB9APDE3BPDE3A | |
| SCHEMBL1129657 | 0.73 | ALDH1A1 (0.39) | NPC1PDE3BPDE3AALDH1A1TP53 | |
| SCHEMBL24922603 | 0.69 | NPC1 (0.44) | POLBNPC1RAB9AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8518939-B2 | 6-pyrimidinyl-pyrimid-4-one derivative | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2013-08-27 | — | — | US | disclosed |
| EP-2197877-B1 | 3-METHYL-2- ( (2S) -2- (4- (3-METHYL-1, 2, 4-OXADIAZOL-5-YL) PHENYL) MORPHOLINO) -6- (PYRIMIDIN-4-YL) PYRIMIDIN-4 (3H) -ONE AS TAU PROTEIN KINASE INHIBITOR | SANOFI SA (FR) | 2013-05-15 | — | — | EP | disclosed |
| EP-2193129-B1 | 6-PYRIMIDINYL-PYRIMID-2-ONE DERIVATIVE | MITSUBISHI TANABE PHARMA CORP (JP) | 2012-10-24 | — | — | EP | disclosed |
| US-8288383-B2 | 3-methyl-2- ( (2S) -2- (4- (3-methyl-L, 2, 4-oxadiazol-5-YL) phenyl) morpholino) -6- (pyrim-idin-4-yl) pyrimidin-4 (3H) -one as tau protein kinase inhibitor | SANOFI (FR) | 2012-10-16 | — | — | US | disclosed |
| US-20120252812-A1 | 6-PYRIMIDINYL-PYRIMID-4-ONE DERIVATIVE | SANOFI-AVENTIS (FR) | 2012-10-04 | — | — | US | disclosed |
| US-8198437-B2 | 6-pyrimidinyl-pyrimid-4-one derivative | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2012-06-12 | — | — | US | disclosed |
| US-20110021773-A1 | 6-PYRIMIDINYL-PYRIMID-4-ONE DERIVATIVE | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2011-01-27 | — | — | US | disclosed |
| US-20110003988-A1 | 3-METHYL-2- ( (2S) -2- (4- (3-METHYL-L, 2, 4-0XADIAZ0L-5-YL) PHENYL) MORPHOLINO) -6- (PYRIM-IDIN-4-YL) PYRIMIDIN-4 (3H) -ONE AS TAU PROTEIN KINASE INHIBITOR | SANOFI-AVENTIS (FR) | 2011-01-06 | — | — | US | disclosed |
| CN-101883770-A | 6-pyrimidinyl-pyrimid-2-one derivative | MITSUBISHI TANABE PHARMA CORP | 2010-11-10 | — | — | CN | disclosed |
| CN-101883770-A | 6-pyrimidinyl-pyrimid-2-one derivative | MITSUBISHI TANABE PHARMA CORP | 2010-11-10 | — | — | CN | disclosed |
| CN-101842371-A | 3-methyl-2- ( (2s) -2- (4- (3-methyl-l, 2, 4-0xadiaz0l-5-yl) phenyl) morpholino) -6- (pyrimidin-4-yl) pyrimidin-4 (3h) -one as tau protein kinase inhibitor | SANOFI AVENTIS | 2010-09-22 | — | — | CN | disclosed |
| EP-2197877-A1 | 3-METHYL-2- ( (2S) -2- (4- (3-METHYL-L, 2, 4-0XADIAZ0L-5-YL) PHENYL) MORPHOLINO) -6- (PYRIMIDIN-4-YL) PYRIMIDIN-4 (3H) -ONE AS TAU PROTEIN KINASE INHIBITOR | Sanofi-Aventis (FR) | 2010-06-23 | — | — | EP | disclosed |
| EP-2193129-A1 | 6-PYRIMIDINYL-PYRIMID-2-ONE DERIVATIVE | Mitsubishi Tanabe Pharma Corporation (JP) | 2010-06-09 | — | — | EP | disclosed |
| EP-2078717-A1 | 6-Pyrimidinyl-pyrimid-2-one derivative | sanofi-aventis (FR) | 2009-07-15 | — | — | EP | disclosed |
| EP-2078717-A1 | 6-Pyrimidinyl-pyrimid-2-one derivative | sanofi-aventis (FR) | 2009-07-15 | — | — | EP | disclosed |
| WO-2009035162-A1 | 6-PYRIMIDINYL-PYRIMID-2-ONE DERIVATIVE | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2009-03-19 | — | — | WO | disclosed |
| WO-2009035159-A1 | 3-METHYL-2- ( (2S) -2- (4- (3-METHYL-L, 2, 4-0XADIAZ0L-5-YL) PHENYL) MORPHOLINO) -6- (PYRIMIDIN-4-YL) PYRIMIDIN-4 (3H) -ONE AS TAU PROTEIN KINASE INHIBITOR | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2009-03-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120252812-A1 | 6-PYRIMIDINYL-PYRIMID-4-ONE DERIVATIVE | MAPT, PSEN1, PSEN2 | POLB 1143/4885NPC1 576/4885RAB9A 1344/4885 |
| US-20110003988-A1 | 3-METHYL-2- ( (2S) -2- (4- (3-METHYL-L, 2, 4-0XADIAZ0L-5-YL) PHENYL) MORPHOLINO) -6- (PYRIM-IDIN-4-YL) PYRIMIDIN-4 (3H) -ONE AS TAU PROTEIN KINASE INHIBITOR | MAPT, PSEN2, PSEN1 | POLB 2435/4885NPC1 1398/4885RAB9A 1741/4885 |
| US-20110021773-A1 | 6-PYRIMIDINYL-PYRIMID-4-ONE DERIVATIVE | MAPT, PSEN1, PSEN2 | POLB 1143/4885NPC1 576/4885RAB9A 1344/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.