Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | NOS2 | P35228 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL336131 | 1.00 | SMN1; SMN2 (0.59) | SMN1; SMN2NOS2POLBCYP1A2CYP2D6 | |
| SCHEMBL30621933 | 0.98 | SMN1; SMN2 (0.61) | SMN1; SMN2NOS2POLBCYP1A2CYP2D6 | |
| SCHEMBL149707 | 0.98 | SMN1; SMN2 (0.61) | SMN1; SMN2NOS2POLBCYP1A2CYP2D6 | |
| SCHEMBL27588340 | 0.78 | POLB (0.49) | SMN1; SMN2NOS2POLBCYP1A2CYP2D6 | |
| SCHEMBL28115610 | 0.78 | RAB9A (0.48) | SMN1; SMN2POLBHTTKDM4ENPC1 | |
| Iodide SCHEMBL336205 | 0.77 | SMN1; SMN2 (0.61) | SMN1; SMN2POLBHTTKDM4ENPC1 | |
| Iodide SCHEMBL336206 | 0.77 | SMN1; SMN2 (0.61) | SMN1; SMN2POLBHTTKDM4ENPC1 | |
| Iodide SCHEMBL27898886 | 0.77 | SMN1; SMN2 (0.61) | SMN1; SMN2POLBHTTKDM4ENPC1 | |
| SCHEMBL21555494 | 0.76 | KDM4E (0.65) | SMN1; SMN2NOS2POLBCYP1A2CYP2D6 | |
| SCHEMBL1171430 | 0.76 | MEN1 (0.69) | SMN1; SMN2POLBHTTKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8097756-B2 | Process for producing carboxylic acid anhydrides | CHINA PETROCHEMICAL DEVELOPMENT CORPORATION (TW) | 2012-01-17 | — | — | US | claimed |
| US-20100145098-A1 | PROCESS FOR PRODUCING CARBOXYLIC ACID ANHYDRIDES | CHINA PETROCHEMICAL DEVELOPMENT CORPORATION (TW) | 2010-06-10 | — | — | US | claimed |
| US-8097756-B2 | Process for producing carboxylic acid anhydrides | CHINA PETROCHEMICAL DEVELOPMENT CORPORATION (TW) | 2012-01-17 | — | — | US | disclosed |
| US-20100145098-A1 | PROCESS FOR PRODUCING CARBOXYLIC ACID ANHYDRIDES | CHINA PETROCHEMICAL DEVELOPMENT CORPORATION (TW) | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100145098-A1 | PROCESS FOR PRODUCING CARBOXYLIC ACID ANHYDRIDES | CA4, CA9, CA7 | SMN1; SMN2 2703/4885NOS2 40/4885POLB 362/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.