Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 5/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 5/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3043816 | 0.93 | HCRTR1 (0.39) | HCRTR1HCRTR2 | |
| SCHEMBL3002225 | 0.90 | HCRTR1 (0.34) | HCRTR1HCRTR2 | |
| SCHEMBL3055330 | 0.87 | SCN9A (0.34) | HCRTR1HCRTR2SCN9A | |
| SCHEMBL3640420 | 0.87 | SCN9A (0.34) | HCRTR1HCRTR2SCN9A | |
| SCHEMBL3363371 | 0.86 | HCRTR1 (0.41) | HCRTR1HCRTR2 | |
| SCHEMBL3361282 | 0.86 | PTPRB (0.36) | HCRTR1HCRTR2SCN9A | |
| SCHEMBL3638060 | 0.86 | PTPRB (0.36) | HCRTR1HCRTR2SCN9A | |
| SCHEMBL3365575 | 0.86 | HCRTR1 (0.36) | HCRTR1HCRTR2 | |
| SCHEMBL3641223 | 0.85 | HCRTR1 (0.38) | HCRTR1HCRTR2 | |
| SCHEMBL3045164 | 0.85 | HCRTR1 (0.38) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155739-B1 | 2-CYCLOPROPYL-THIAZOLE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-10-06 | — | — | EP | disclosed |