Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 4/20 | 0.34 |
| ▸ | CCKAR | P32238 | 2/20 | 0.34 |
| ▸ | CCKBR | P32239 | 2/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3055330 | 1.00 | SCN9A (0.34) | SCN9ACCKARCCKBRSLC6A3SLC6A2 | |
| SCHEMBL3101893 | 0.90 | CCKAR (0.35) | CCKARCCKBRSLC6A3SLC6A2SLC6A4 | |
| SCHEMBL3361887 | 0.87 | HCRTR1 (0.39) | SCN9AHCRTR1HCRTR2 | |
| SCHEMBL3363371 | 0.85 | HCRTR1 (0.41) | HCRTR1HCRTR2 | |
| SCHEMBL3361282 | 0.85 | PTPRB (0.36) | SCN9ASLC6A3SLC6A2SLC6A4LMNA | |
| SCHEMBL3638060 | 0.85 | PTPRB (0.36) | SCN9ASLC6A3SLC6A2SLC6A4LMNA | |
| SCHEMBL3043816 | 0.85 | HCRTR1 (0.39) | HCRTR1HCRTR2 | |
| SCHEMBL3365575 | 0.84 | HCRTR1 (0.36) | HCRTR1HCRTR2 | |
| SCHEMBL3046412 | 0.82 | LMNA (0.40) | LMNAHCRTR1HCRTR2 | |
| SCHEMBL3636572 | 0.82 | LMNA (0.40) | LMNAHCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155739-A1 | 2-CYCLOPROPYL-THIAZOLE DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008139416-A1 | 2-CYCLOPROPYL-THIAZOLE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2008-11-20 | — | — | WO | disclosed |