Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 7/20 | 0.53 |
| ▸ | GRIN2A | Q12879 | 7/20 | 0.53 |
| ▸ | GRIN2D | O15399 | 6/20 | 0.53 |
| ▸ | GRIN3B | O60391 | 6/20 | 0.53 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.53 |
| ▸ | GRIN2C | Q14957 | 6/20 | 0.53 |
| ▸ | GRIN3A | Q8TCU5 | 6/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.39 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | STAT6 | P42226 | 1/20 | 0.39 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6904418 | 0.86 | GRIN2D (0.38) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| SCHEMBL31732784 | 0.82 | GRIN2D (0.47) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| SCHEMBL31732782 | 0.80 | GRIN2D (0.45) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| SCHEMBL14149404 | 0.78 | GRIN2D (0.33) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| SCHEMBL10414911 | 0.78 | TSHR (0.35) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| SCHEMBL1397855 | 0.78 | GRIN2D (0.34) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| SCHEMBL3360868 | 0.78 | GRIN1 (0.48) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| SCHEMBL5917754 | 0.77 | PKM (0.42) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| SCHEMBL10414910 | 0.77 | GRIN2D (0.32) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| SCHEMBL270387 | 0.77 | NPSR1 (0.43) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2662727-A2 | Compound for resist and radiation-sensitive composition | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2013-11-13 | — | — | EP | disclosed |
| US-8569250-B2 | Organic compounds | NOVARTIS AG (CH) | 2013-10-29 | — | — | US | disclosed |
| EP-2247602-B1 | ADAMANTYL O-GLUCURONIDE DERIVATIVES AS INHIBITORS OF DIPEPTIDYL PEPTIDASE IV FOR THE TREATMENT OF DIABETES | NOVARTIS AG (CH) | 2013-04-03 | — | — | EP | disclosed |
| US-20120295860-A1 | ORGANIC COMPOUNDS | HASSIEPEN ULRICH (DE) | 2012-11-22 | — | — | US | disclosed |
| US-8252751-B2 | Organic compounds | NOVARTIS AG (CH) | 2012-08-28 | — | — | US | disclosed |
| EP-2247602-A2 | ADAMANTYL O-GLUCURONIDE DERIVATIVES AS INHIBITORS OF DIPEPTIDYL PEPTIDASE IV FOR THE TREATMENT OF DIABETES | Novartis AG (CH) | 2010-11-10 | — | — | EP | disclosed |
| US-20100256080-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2010-10-07 | — | — | US | disclosed |
| WO-2009068531-A2 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2009-06-04 | — | — | WO | disclosed |
| EP-1137635-B1 | N-SUBSTITUTED 2-CYANOPYRROLIDINES | NOVARTIS AG (CH) | 2005-10-19 | — | — | EP | disclosed |
| EP-1137635-A1 | N-SUBSTITUTED 2-CYANOPYRROLIDINES | Novartis AG (CH) | 2001-10-04 | — | — | EP | disclosed |
| US-6166063-A | N-(substituted glycyl)-2-cyanopyrrolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV | NOVARTIS AG (CH) | 2000-12-26 | — | — | US | disclosed |
| WO-2000034241-A1 | N-SUBSTITUTED 2-CYANOPYRROLIDINES | NOVARTIS AG (CH) | 2000-06-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256080-A1 | ORGANIC COMPOUNDS | DPP4, DPP7, DPP3 | GRIN1 2880/4885GRIN2A 3441/4885GRIN2D 3421/4885 |
| US-20120295860-A1 | ORGANIC COMPOUNDS | DPP4, DPP7, DPP3 | GRIN1 2860/4885GRIN2A 3430/4885GRIN2D 3406/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.