Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Triethylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetraethylene Glycol SCHEMBL321240 | 0.90 | MEN1 (0.52) | MEN1KMT2ATHRBHTTMAPT | |
| Triethylene Glycol SCHEMBL2967311 | 0.88 | MEN1 (0.50) | MEN1KMT2ATHRBHTTMAPT | |
| Di(Hydroxyethyl)Ether SCHEMBL3067562 | 0.88 | TSHR (0.50) | MEN1KMT2ATHRBHTTMAPT | |
| Triethylene Glycol SCHEMBL6745987 | 0.88 | MEN1 (0.55) | MEN1KMT2ATHRBHTTMAPT | |
| Di(Hydroxyethyl)Ether SCHEMBL7206342 | 0.85 | TSHR (0.53) | MEN1KMT2ATHRBHTTMAPT | |
| Tetraethylene Glycol SCHEMBL150370 | 0.84 | MEN1 (0.46) | MEN1KMT2ATHRBHTTMAPT | |
| Propylene Glycol SCHEMBL3359839 | 0.83 | MEN1 (0.61) | MEN1KMT2ATHRBHTTMAPT | |
| Triethylene Glycol SCHEMBL6869496 | 0.83 | MEN1 (0.61) | MEN1KMT2ATHRBHTTMAPT | |
| Triethylene Glycol SCHEMBL22077278 | 0.83 | MEN1 (0.61) | MEN1KMT2ATHRBHTTMAPT | |
| Propylene Glycol SCHEMBL8851056 | 0.83 | MEN1 (0.61) | MEN1KMT2ATHRBHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7697874-B2 | Developer supply roller and image forming apparatus | RICOH COMPANY, LTD. (JP) | 2010-04-13 | — | — | US | disclosed |
| US-20080232864-A1 | DEVELOPER SUPPLY ROLLER AND IMAGE FORMING APPARATUS | RICOH COMPANY, LTD. (JP) | 2008-09-25 | — | — | US | disclosed |