Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 8/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.50 |
| ▸ | ABAT | P80404 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9154630 | 0.86 | ALDH1A1 (0.39) | CYP3A4ALOX15TP53ALOX12ALDH1A1 | |
| SCHEMBL111720 | 0.80 | IDO1 (0.50) | ESR1ESR2ABATLMNACYP3A4 | |
| SCHEMBL13743996 | 0.80 | IDO1 (0.50) | ESR1ESR2ABATLMNACYP3A4 | |
| SCHEMBL111719 | 0.80 | IDO1 (0.50) | ESR1ESR2ABATLMNACYP3A4 | |
| SCHEMBL448422 | 0.78 | ESR1 (0.55) | ESR1ESR2ABATLMNACYP3A4 | |
| SCHEMBL448421 | 0.78 | ESR1 (0.55) | ESR1ESR2ABATLMNACYP3A4 | |
| SCHEMBL105690 | 0.76 | ESR1 (0.52) | ESR1ESR2ABATLMNACYP3A4 | |
| SCHEMBL9249830 | 0.76 | TP53 (0.46) | LMNACA2TP53CYP2C9TAAR1 | |
| SCHEMBL3805915 | 0.76 | ESR1 (0.52) | ESR1ESR2ABATLMNACYP3A4 | |
| SCHEMBL3465880 | 0.76 | IDO1 (0.48) | LMNACA2MAPTTP53CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 80 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8383637-B2 | 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) | JANSSSEN PHARMACEUTICA N.V. (BE) | 2013-02-26 | — | — | US | claimed |
| EP-1776349-B1 | 2-AMINO-QUINAZOLINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE) | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-06 | — | — | EP | claimed |
| CN-101035771-A | 2-amino-quinazoline derivatives useful as inhibitors of beta-secretase (BACE) | JANSSEN PHARMACEUTICA NV (BE) | 2007-09-12 | — | — | CN | claimed |
| EP-1776349-A2 | 2-AMINO-QUINAZOLINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE) | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-04-25 | — | — | EP | claimed |
| US-20060079687-A1 | Novel 2-amino-quinazoline derivatives useful as inhibitors of beta-secretase (BACE) | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-04-13 | — | — | US | claimed |
| WO-2006017836-A2 | 2-AMINO-QUINAZOLINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE) | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-02-16 | — | — | WO | claimed |
| US-5364948-A | Anticancer, anticholesterol, fungicide | MERCK & CO., INC. (US) | 1994-11-15 | — | — | US | claimed |
| US-5049587-A | Mabuterol | BASOTHERM GMBH (DE) | 1991-09-17 | — | — | US | claimed |
| US-4119710-A | ANALGESICS, UTEROSPASMOLYTICS, ANTISPASTICS, BLOCKING AGENTS | BOEHRINGER INGELHEIM GMBH (DE) | 1978-10-10 | — | — | US | claimed |
| US-3996383-A | 3-Alkylamino-α-aminomethyl-4-hydroxybenzyl alcohols with β-adrenergic stimulant activity | SMITHKLINE CORPORATION (US) | 1976-12-07 | — | — | US | claimed |
| US-3943173-A | 3-Alkylamino- alpha-aminomethyl-4-hydroxybenzyl alcohols | SMITHKLINE CORPORATION (US) | 1976-03-09 | — | — | US | claimed |
| US-11149028-B2 | Methods for treating melanoma using small molecules | NOVA SOUTHEASTERN UNIVERSITY (US) | 2021-10-19 | — | — | US | disclosed |
| EP-3849311-A1 | FUNGICIDAL HALOMETHYL KETONES AND HYDRATES | FMC Corporation (US) | 2021-07-21 | — | — | EP | disclosed |
| WO-2020056090-A1 | FUNGICIDAL HALOMETHYL KETONES AND HYDRATES | FMC CORPORATION (US) | 2020-03-19 | — | — | WO | disclosed |
| US-20200062736-A1 | METHODS FOR TREATING MELANOMA USING SMALL MOLECULES AND SMALL INTERFERING RNA (siRNA) | NOVA SOUTHEASTERN UNIVERSITY (US) | 2020-02-27 | — | — | US | disclosed |
| US-4001421-A | THIAZOLE CARDIOVASCULAR AGENTS | SYNTEX (U.S.A.) INC. (US) | 1977-01-04 | — | — | US | disclosed |
| US-3996383-A | 3-Alkylamino-α-aminomethyl-4-hydroxybenzyl alcohols with β-adrenergic stimulant activity | SMITHKLINE CORPORATION (US) | 1976-12-07 | — | — | US | disclosed |
| US-3982010-A | Thiazole cardiovascular agents | SYNTEX (U.S.A.) INC. (US) | 1976-09-21 | — | — | US | disclosed |
| US-3978041-A | CARDIAC INSUFFICIENCY | CIBA-GEIGY CORPORATION (US) | 1976-08-31 | — | — | US | disclosed |
| US-3943173-A | 3-Alkylamino- alpha-aminomethyl-4-hydroxybenzyl alcohols | SMITHKLINE CORPORATION (US) | 1976-03-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11149028-B2 | Methods for treating melanoma using small molecules | DDX1, HNRNPH3, HNRNPA2B1 | ESR1 2902/4885ESR2 1684/4885ABAT 4507/4885 |
| US-20060079687-A1 | Novel 2-amino-quinazoline derivatives useful as inhibitors of beta-secretase (BACE) | BACE2, BACE1, APP | ESR1 3103/4885ESR2 1446/4885ABAT 401/4885 |
| US-20200062736-A1 | METHODS FOR TREATING MELANOMA USING SMALL MOLECULES AND SMALL INTERFERING RNA (siRNA) | HNRNPH3, DDX1, HNRNPH1 | ESR1 2831/4885ESR2 1838/4885ABAT 4418/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.