Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 8/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | CLK3 | P49761 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.34 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 3/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | CD63 | P08962 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3362577 | 0.88 | DYRK1A (0.48) | CLK2CLK3DYRK1APIK3CAZAP70 | |
| SCHEMBL3360215 | 0.88 | PTK2 (0.39) | TBK1PTK2PIK3CAZAP70EGFR | |
| SCHEMBL3357806 | 0.79 | DYRK1A (0.40) | CLK2CLK3DYRK1APIK3CAZAP70 | |
| SCHEMBL3363124 | 0.78 | ZAP70 (0.46) | ZAP70 | |
| SCHEMBL1050424 | 0.77 | ZAP70 (0.57) | CLK2CLK3DYRK1AZAP70 | |
| SCHEMBL3362294 | 0.76 | BCHE (0.45) | EGFRJAK2SYK | |
| SCHEMBL3359494 | 0.75 | CSF1R (0.34) | PIK3CAMTORZAP70CD63SYK | |
| SCHEMBL3362472 | 0.74 | ZAP70 (0.42) | PIK3CAMTORZAP70CD63SYK | |
| SCHEMBL3362594 | 0.73 | ZAP70 (0.55) | PIK3CAMTORZAP70JAK2CD63 | |
| SCHEMBL3362714 | 0.72 | ABL1 (0.45) | PIK3CAMTORZAP70JAK2CD63 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | disclosed |