Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 7/20 | 0.48 |
| ▸ | CLK2 | P49760 | 3/20 | 0.48 |
| ▸ | CLK3 | P49761 | 3/20 | 0.48 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.41 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 6/20 | 0.38 |
| ▸ | WEE1 | P30291 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | WNT1 | P04628 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 3/20 | 0.35 |
| ▸ | CD63 | P08962 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3357806 | 0.90 | DYRK1A (0.40) | DYRK1ACLK2CLK3ZAP70GSK3B | |
| SCHEMBL3362712 | 0.88 | TBK1 (0.36) | DYRK1ACLK2CLK3ZAP70PIK3CA | |
| SCHEMBL3363124 | 0.88 | ZAP70 (0.46) | ZAP70BRD4 | |
| SCHEMBL3360034 | 0.82 | ZAP70 (0.45) | DYRK1AZAP70CAMK2DGSK3BWEE1 | |
| SCHEMBL3362467 | 0.81 | ZAP70 (0.49) | ZAP70PIK3CABRD4 | |
| SCHEMBL3360687 | 0.79 | ZAP70 (0.47) | ZAP70BRD4 | |
| SCHEMBL3362632 | 0.79 | ZAP70 (0.45) | ZAP70SYKBRD4 | |
| SCHEMBL3360215 | 0.78 | PTK2 (0.39) | ZAP70PIK3CASYK | |
| SCHEMBL3362296 | 0.78 | ZAP70 (0.49) | ZAP70BRD4 | |
| SCHEMBL1047642 | 0.78 | ZAP70 (0.67) | DYRK1ACLK2CLK3ZAP70CAMK2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | disclosed |