Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL324419 | 1.00 | CYP2A6 (0.44) | CYP2A6TDP1L3MBTL1KCNH2LMNA | |
| Bromide SCHEMBL3363614 | 1.00 | CYP2A6 (0.44) | CYP2A6TDP1L3MBTL1KCNH2LMNA | |
| Bromide SCHEMBL28200041 | 1.00 | CYP2A6 (0.44) | CYP2A6TDP1L3MBTL1KCNH2LMNA | |
| Bromide SCHEMBL25259916 | 1.00 | CYP2A6 (0.44) | CYP2A6TDP1L3MBTL1KCNH2LMNA | |
| Bromide SCHEMBL2206823 | 1.00 | CYP2A6 (0.44) | CYP2A6TDP1L3MBTL1KCNH2LMNA | |
| Bromide SCHEMBL25252655 | 1.00 | CYP2A6 (0.44) | CYP2A6TDP1L3MBTL1KCNH2LMNA | |
| Bromide SCHEMBL17317381 | 1.00 | CYP2A6 (0.44) | CYP2A6TDP1L3MBTL1KCNH2LMNA | |
| Bromide SCHEMBL31028773 | 1.00 | CYP2A6 (0.44) | CYP2A6TDP1L3MBTL1KCNH2LMNA | |
| Bromide SCHEMBL3363045 | 1.00 | CYP2A6 (0.44) | CYP2A6TDP1L3MBTL1KCNH2LMNA | |
| Bromide SCHEMBL27618632 | 0.98 | CYP2A6 (0.43) | CYP2A6TDP1L3MBTL1KCNH2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8367358-B2 | Reagent, kit and method for differentiating and counting leukocytes | SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD. (CN) | 2013-02-05 | — | — | US | claimed |
| US-20100151509-A1 | REAGENT, KIT AND METHOD FOR DIFFERENTATING AND COUNTING LEUKOCYTES | SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD. (CN) | 2010-06-17 | — | — | US | claimed |
| US-8367358-B2 | Reagent, kit and method for differentiating and counting leukocytes | SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD. (CN) | 2013-02-05 | — | — | US | disclosed |
| US-20100151509-A1 | REAGENT, KIT AND METHOD FOR DIFFERENTATING AND COUNTING LEUKOCYTES | SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD. (CN) | 2010-06-17 | — | — | US | disclosed |