Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5577881 | 0.89 | MAP2K1 (0.52) | MAP2K1MAP2K2 | |
| SCHEMBL18133378 | 0.87 | MAP2K1 (0.58) | MAP2K1MAP2K2 | |
| SCHEMBL3362332 | 0.86 | MAP2K1 (0.49) | MAP2K1MAP2K2 | |
| SCHEMBL1516548 | 0.82 | MAP2K1 (0.66) | MAP2K1MAP2K2 | |
| SCHEMBL391857 | 0.80 | MAP2K1 (0.78) | MAP2K1MAP2K2 | |
| SCHEMBL13113251 | 0.78 | MAP2K1 (0.50) | MAP2K1MAP2K2 | |
| SCHEMBL15463530 | 0.78 | MAP2K1 (0.56) | MAP2K1MAP2K2 | |
| SCHEMBL1516559 | 0.78 | MAP2K1 (0.70) | MAP2K1MAP2K2 | |
| SCHEMBL393809 | 0.78 | MAP2K1 (0.79) | MAP2K1MAP2K2 | |
| SCHEMBL1516539 | 0.78 | MAP2K1 (0.49) | MAP2K1MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8716318-B2 | Pyridone sulfonamides and pyridone sulfamides as MEK inhibitors | ARDEA BIOSCIENCES (US) | 2014-05-06 | — | — | US | disclosed |
| EP-2012786-B1 | PYRIDONE SULFONAMIDES AND PYRIDONE SULFAMIDES AS MEK INHIBITORS | ARDEA BIOSCIENCES INC (US) | 2010-10-06 | — | — | EP | disclosed |
| US-20070244164-A1 | PYRIDONE SULFONAMIDES AND PYRIDONE SULFAMIDES AS MEK INHIBITORS | ARDEA BIOSCIENCES (US) | 2007-10-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070244164-A1 | PYRIDONE SULFONAMIDES AND PYRIDONE SULFAMIDES AS MEK INHIBITORS | BRAF, PDXK, MAP3K20 | MAP2K1 38/4885MAP2K2 25/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.