Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | COMT | P21964 | 15/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3365763 | 0.85 | COMT (0.65) | COMTCDK2 | |
| SCHEMBL3364756 | 0.83 | COMT (0.61) | COMTKMT2ACDK2 | |
| SCHEMBL1609327 | 0.83 | COMT (0.69) | COMTSMN1; SMN2FTOKMT2A | |
| SCHEMBL1608934 | 0.76 | COMT (0.83) | COMTMEN1KMT2A | |
| SCHEMBL3365925 | 0.76 | COMT (0.59) | COMTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL3362922 | 0.74 | COMT (0.55) | COMTLMNASMN1; SMN2TSHRMEN1 | |
| SCHEMBL1608186 | 0.74 | COMT (0.73) | COMTCDK2 | |
| SCHEMBL1608305 | 0.67 | COMT (0.46) | COMTLMNASMN1; SMN2KMT2A | |
| SCHEMBL1608782 | 0.67 | COMT (0.68) | COMTMEN1KMT2A | |
| SCHEMBL30592877 | 0.67 | COMT (0.68) | COMTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910325-B1 | NEW PHARMACEUTICAL COMPOUNDS | ORION CORP (FI) | 2010-10-06 | — | — | EP | claimed |