Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 17/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | USP19 | O94966 | 1/20 | 0.38 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3364467 | 0.97 | GSK3B (0.42) | GSK3BCYP1A2CYP2D6CDC7ROCK2 | |
| SCHEMBL3369881 | 0.97 | GSK3B (0.42) | GSK3BCYP1A2CYP2D6CDC7ROCK2 | |
| SCHEMBL3370809 | 0.83 | GSK3B (0.47) | GSK3BCYP1A2CYP2D6 | |
| SCHEMBL3367409 | 0.83 | GSK3B (0.47) | GSK3BCYP1A2CYP2D6 | |
| SCHEMBL3365321 | 0.80 | GSK3B (0.50) | GSK3BCYP1A2CYP2D6 | |
| SCHEMBL3364870 | 0.79 | GSK3B (0.47) | GSK3BCYP1A2CYP2D6 | |
| SCHEMBL3366954 | 0.78 | GSK3B (0.48) | GSK3BCYP1A2CYP2D6 | |
| SCHEMBL3364502 | 0.78 | GSK3B (0.48) | GSK3BCYP1A2CYP2D6USP19 | |
| SCHEMBL3366822 | 0.78 | GSK3B (0.48) | GSK3BCYP1A2CYP2D6USP19 | |
| SCHEMBL3366917 | 0.78 | GSK3B (0.48) | GSK3BCYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603915-B1 | SUBSTITUTED 8 -PYRIDINYL-DIHYDROSPIRO- CYCLOALKYL -PYRIMIDO 1,2-a PYRIMIDIN-6-ONE AND 8 -PYRIMIDIN YL-DIHYDROSPIRO- CYCLOALKYL -PYRIMIDO 1,2-a PYRIMIDIN-6-ONE DERIVATIVES AND THEIR USE AGAINST NEUROGENERATIVE DISEASES | SANOFI AVENTIS (FR) | 2010-05-26 | — | — | EP | claimed |