Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM2 | Q9P1W9 | 12/20 | 0.72 |
| ▸ | PIM1 | P11309 | 2/20 | 0.63 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.63 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.63 |
| ▸ | RAD52 | P43351 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.42 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2214990 | 0.85 | PIM2 (0.74) | PIM2PIM1CSNK2A2CSNK2A1RAD52 | |
| SCHEMBL2213805 | 0.84 | PIM2 (1.00) | PIM2PIM1CSNK2A2CSNK2A1RAD52 | |
| SCHEMBL3363434 | 0.83 | PIM2 (0.59) | PIM2PIM1CSNK2A2CSNK2A1RAD52 | |
| SCHEMBL3364833 | 0.81 | PIM2 (0.68) | PIM2PIM1CSNK2A2CSNK2A1RAD52 | |
| SCHEMBL2212264 | 0.78 | PIM2 (0.74) | PIM2PIM1CSNK2A2CSNK2A1RAD52 | |
| SCHEMBL2212257 | 0.78 | PIM2 (0.74) | PIM2PIM1CSNK2A2CSNK2A1RAD52 | |
| SCHEMBL2214184 | 0.78 | PIM2 (1.00) | PIM2PIM1CSNK2A2CSNK2A1 | |
| SCHEMBL2212990 | 0.78 | PIM2 (1.00) | PIM2PIM1CSNK2A2CSNK2A1 | |
| SCHEMBL3363431 | 0.77 | PIM2 (0.58) | PIM2PIM1CSNK2A2CSNK2A1DYRK1A | |
| SCHEMBL2211571 | 0.77 | PIM2 (1.00) | PIM2PIM1CSNK2A2CSNK2A1RAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010148351-A1 | RHODANINES AND RELATED HETEROCYCLES AS KINASE INHIBITORS | CYLENE PHARMACEUTICALS, INC. (US) | 2010-12-23 | — | — | WO | disclosed |