Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM2 | Q9P1W9 | 13/20 | 0.59 |
| ▸ | PIM1 | P11309 | 6/20 | 0.52 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.52 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12989801 | 0.86 | PIM2 (0.62) | PIM2PIM1CSNK2A2CSNK2A1PIM3 | |
| SCHEMBL3366668 | 0.86 | PIM2 (0.62) | PIM2PIM1CSNK2A2CSNK2A1PIM3 | |
| SCHEMBL3366675 | 0.86 | PIM2 (0.62) | PIM2PIM1CSNK2A2CSNK2A1PIM3 | |
| SCHEMBL3364837 | 0.83 | PIM2 (0.72) | PIM2PIM1CSNK2A2CSNK2A1DYRK1A | |
| SCHEMBL3362773 | 0.80 | PIM2 (0.48) | PIM2PIM1CSNK2A2CSNK2A1DYRK1A | |
| SCHEMBL3362769 | 0.80 | PIM2 (0.48) | PIM2PIM1CSNK2A2CSNK2A1DYRK1A | |
| SCHEMBL3362857 | 0.80 | PIM2 (0.51) | PIM2PIM1CSNK2A2CSNK2A1DYRK1A | |
| SCHEMBL3362852 | 0.80 | PIM2 (0.51) | PIM2PIM1CSNK2A2CSNK2A1DYRK1A | |
| SCHEMBL13035905 | 0.80 | PIM2 (0.47) | PIM2PIM1CSNK2A2CSNK2A1DYRK1A | |
| SCHEMBL3362086 | 0.80 | PIM2 (0.47) | PIM2PIM1CSNK2A2CSNK2A1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010148351-A1 | RHODANINES AND RELATED HETEROCYCLES AS KINASE INHIBITORS | CYLENE PHARMACEUTICALS, INC. (US) | 2010-12-23 | — | — | WO | disclosed |