Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6543487 | 0.85 | NOTUM (0.55) | NOTUMOPRM1BCHEGAASMN1; SMN2 | |
| SCHEMBL3363958 | 0.85 | NOTUM (0.50) | NOTUMBCHEROCK2ROCK1HDAC1 | |
| SCHEMBL28312084 | 0.76 | SLC18A3 (0.46) | NOTUMALDH1A1SMN1; SMN2HDAC1HDAC8 | |
| SCHEMBL6544398 | 0.73 | NPC1 (0.51) | NOTUML3MBTL1GAASMN1; SMN2AKT1 | |
| SCHEMBL14529913 | 0.73 | NOTUM (0.57) | NOTUMAKT1ROCK2ROCK1HDAC1 | |
| Hydrochloric Acid SCHEMBL7565105 | 0.72 | NPC1 (0.50) | NOTUML3MBTL1GAASMN1; SMN2AKT1 | |
| SCHEMBL14530335 | 0.72 | HDAC1 (0.59) | NOTUML3MBTL1ALDH1A1GAASMN1; SMN2 | |
| SCHEMBL29644467 | 0.70 | NOTUM (0.57) | NOTUMAKT1ROCK2ROCK1HDAC1 | |
| SCHEMBL6543338 | 0.70 | NOTUM (0.57) | NOTUMAKT1ROCK2ROCK1HDAC1 | |
| Hydrochloric Acid SCHEMBL7497468 | 0.70 | NOTUM (0.39) | NOTUMALDH1A1SMN1; SMN2AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996590-B1 | SPIROINDOLINONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2010-10-06 | — | — | EP | disclosed |
| EP-1996590-A1 | SPIROINDOLINONE DERIVATIVES | F. Hoffmann-la Roche AG (CH) | 2008-12-03 | — | — | EP | disclosed |
| WO-2007104664-A1 | SPIROINDOLINONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-09-20 | — | — | WO | disclosed |