Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.50 |
| ▸ | KDM1A | O60341 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1222469 | 0.86 | NOTUM (0.53) | NOTUMKDM1AHDAC1HDAC6HDAC8 | |
| SCHEMBL30413026 | 0.86 | NOTUM (0.53) | NOTUMKDM1AHDAC1HDAC6HDAC8 | |
| SCHEMBL3364860 | 0.85 | NOTUM (0.51) | NOTUMHDAC1HDAC6HDAC8BCHE | |
| Hydrochloric Acid SCHEMBL25232027 | 0.85 | NOTUM (0.52) | NOTUMKDM1AHDAC1HDAC6HDAC8 | |
| SCHEMBL17807330 | 0.84 | NOTUM (0.64) | NOTUMKDM1AHDAC1HDAC6HDAC8 | |
| SCHEMBL13085702 | 0.79 | KDM1A (0.56) | NOTUMKDM1AHDAC1HDAC6HDAC8 | |
| SCHEMBL29384374 | 0.79 | KDM1A (0.56) | NOTUMKDM1AHDAC1HDAC6HDAC8 | |
| SCHEMBL25350959 | 0.79 | NOTUM (0.53) | NOTUMKDM1AHDAC1HDAC6HDAC8 | |
| SCHEMBL30898670 | 0.79 | NOTUM (0.53) | NOTUMKDM1AHDAC1HDAC6HDAC8 | |
| SCHEMBL15676941 | 0.79 | NOTUM (0.53) | NOTUMKDM1AHDAC1HDAC6HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996590-B1 | SPIROINDOLINONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2010-10-06 | — | — | EP | disclosed |