Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 10/20 | 0.46 |
| ▸ | CNR1 | P21554 | 8/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.39 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3366146 | 0.89 | CRHR1 (0.43) | CRHR1CNR1P2RX7SHMT1SHMT2 | |
| Hydrochloric Acid SCHEMBL3366143 | 0.89 | CRHR1 (0.43) | CRHR1CNR1P2RX7SHMT1SHMT2 | |
| SCHEMBL3364385 | 0.89 | CRHR1 (0.41) | CRHR1CNR1P2RX7 | |
| SCHEMBL3364388 | 0.85 | CRHR1 (0.48) | CRHR1 | |
| Hydrochloric Acid SCHEMBL3365148 | 0.84 | CRHR1 (0.47) | CRHR1 | |
| SCHEMBL3363727 | 0.84 | CRHR1 (0.47) | CRHR1 | |
| SCHEMBL14206651 | 0.83 | MAPK8 (0.43) | CNR1 | |
| Hydrochloric Acid SCHEMBL3362608 | 0.83 | CRHR1 (0.46) | CRHR1 | |
| SCHEMBL3364574 | 0.83 | CRHR1 (0.50) | CRHR1 | |
| SCHEMBL3839128 | 0.81 | CRHR1 (0.51) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656353-B1 | GABANERGIC MODULATORS | HOFFMANN LA ROCHE (CH) | 2010-01-27 | — | — | EP | claimed |