Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 5/20 | 0.46 |
| ▸ | F2 | P00734 | 4/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 4/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ACR | P10323 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5812728 | 0.90 | F2 (0.53) | ALDH1A1PRSS1F2PRSS2PRSS3 | |
| SCHEMBL5700154 | 0.81 | MEN1 (0.54) | ALDH1A1PRSS1F2PRSS2PRSS3 | |
| SCHEMBL13241418 | 0.76 | ALDH1A1 (0.62) | ALDH1A1EGFRERBB2KMT2AMEN1 | |
| SCHEMBL4616138 | 0.76 | GAA (0.76) | ALDH1A1EGFRERBB2KMT2AMEN1 | |
| SCHEMBL3369375 | 0.75 | CNR2 (0.52) | ALDH1A1KMT2AGAAHTTLMNA | |
| SCHEMBL12444230 | 0.74 | ALDH1A1 (0.68) | ALDH1A1PRSS1F2PRSS2PRSS3 | |
| SCHEMBL10047339 | 0.74 | ALDH1A1 (0.68) | ALDH1A1PRSS1F2PRSS2PRSS3 | |
| SCHEMBL11368946 | 0.74 | ALDH1A1 (0.50) | ALDH1A1PRSS1F2PRSS2PRSS3 | |
| SCHEMBL12444214 | 0.74 | ALDH1A1 (0.68) | ALDH1A1PRSS1F2PRSS2PRSS3 | |
| SCHEMBL10047313 | 0.74 | ALDH1A1 (0.68) | ALDH1A1PRSS1F2PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1335901-B1 | PHARMACEUTICALLY ACTIVE SULFANILIDE DERIVATIVES | MERCK SERONO SA (CH) | 2010-04-14 | — | — | EP | disclosed |
| EP-1335901-A1 | PHARMACEUTICALLY ACTIVE SULFANILIDE DERIVATIVES | Applied Research Systems ARS Holding N.V. (AN) | 2003-08-20 | — | — | EP | disclosed |
| WO-2002032864-A1 | PHARMACEUTICALLY ACTIVE SULFANILIDE DERIVATIVES | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2002-04-25 | — | — | WO | disclosed |