Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 20/20 | 0.79 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.70 |
| ▸ | KIT | P10721 | 1/20 | 0.70 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.70 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.70 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.70 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.70 |
| ▸ | FLT3 | P36888 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2922233 | 0.88 | PDGFRB (1.00) | PDGFRBPDGFRAKITFGFR1FGFR2 | |
| SCHEMBL3363145 | 0.87 | PDGFRB (0.80) | PDGFRBPDGFRAKITFGFR1FGFR2 | |
| SCHEMBL3365435 | 0.85 | PDGFRB (0.73) | PDGFRBPDGFRAKITFGFR1FGFR2 | |
| SCHEMBL2921454 | 0.84 | PDGFRB (0.88) | PDGFRBPDGFRAKITFGFR1FGFR2 | |
| SCHEMBL2922308 | 0.84 | PDGFRB (0.82) | PDGFRBPDGFRAKITFGFR1FGFR2 | |
| SCHEMBL2921283 | 0.83 | PDGFRB (0.80) | PDGFRBPDGFRAKITFGFR1FGFR2 | |
| SCHEMBL2922665 | 0.83 | PDGFRB (0.80) | PDGFRBPDGFRAKITFGFR1FGFR2 | |
| SCHEMBL2592017 | 0.83 | PDGFRB (1.00) | PDGFRBPDGFRAKITFGFR1FGFR2 | |
| SCHEMBL2921259 | 0.83 | PDGFRB (0.80) | PDGFRBPDGFRAKITFGFR1FGFR2 | |
| SCHEMBL2912640 | 0.82 | PDGFRB (1.00) | PDGFRBPDGFRAKITFGFR1FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309569-B1 | N-aryl-{4-[7-(alkoxy)quinazolin-4-yl]piperazinyl}carboxamide derivatives as PDGFRs inhibitors | MILLENNIUM PHARM INC (US) | 2010-10-06 | — | — | EP | claimed |