Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 4/20 | 0.58 |
| ▸ | BACE1 | P56817 | 3/20 | 0.58 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.57 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | KIT | P10721 | 1/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.51 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | WDR5 | P61964 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6178429 | 0.90 | EIF2AK2 (0.64) | ACHEBACE1HRH4EIF2AK2PDGFRB | |
| SCHEMBL22911861 | 0.88 | ACHE (0.56) | ACHEBACE1PDGFRBHTTKIT | |
| SCHEMBL2922107 | 0.85 | ACHE (0.53) | ACHEBACE1PDGFRBHTTKIT | |
| SCHEMBL11720346 | 0.79 | RHOA (0.63) | ACHEHRH4EIF2AK2SIRT6HRH3 | |
| SCHEMBL6178930 | 0.77 | HRH4 (0.57) | ACHEHRH4EIF2AK2SIRT6HRH3 | |
| SCHEMBL3366711 | 0.77 | HRH4 (0.64) | ACHEBACE1HRH4HTTKMT2A | |
| SCHEMBL3367557 | 0.77 | HTT (0.79) | ACHEBACE1HRH4HTTKMT2A | |
| SCHEMBL28638711 | 0.77 | CYP1A2 (0.67) | ACHEBACE1HRH4PDGFRBHTT | |
| SCHEMBL29594718 | 0.76 | PDGFRB (0.45) | ACHEBACE1PDGFRBKITPDGFRA | |
| SCHEMBL3361468 | 0.75 | PRKDC (0.71) | ACHEBACE1HRH4HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010146173-A1 | QUINAZOLINE DERIVATIVES AS HISTAMINE H4-RECEPT0R INHIBITORS FOR USE IN THE TREATMENT OF INFLAMMATORY DISORDERS | VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG (NL) | 2010-12-23 | — | — | WO | disclosed |
| WO-2010146173-A1 | QUINAZOLINE DERIVATIVES AS HISTAMINE H4-RECEPT0R INHIBITORS FOR USE IN THE TREATMENT OF INFLAMMATORY DISORDERS | VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG (NL) | 2010-12-23 | — | — | WO | disclosed |