Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.56 |
| ▸ | MDM2 | Q00987 | 4/20 | 0.55 |
| ▸ | TGM2 | P21980 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 2/20 | 0.51 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.51 |
| ▸ | TUBB | P07437 | 2/20 | 0.51 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.51 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.51 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.51 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.51 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.51 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.51 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.51 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.51 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.51 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.51 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.51 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4455158 | 1.00 | MEN1 (0.57) | MEN1KMT2APDGFRBMDM2TGM2 | |
| SCHEMBL3367258 | 1.00 | MEN1 (0.57) | MEN1KMT2APDGFRBMDM2TGM2 | |
| SCHEMBL13929384 | 0.91 | MDM2 (0.57) | MEN1KMT2AMDM2TUBB4ATUBB | |
| SCHEMBL276804 | 0.88 | MDM2 (0.55) | PDGFRBMDM2TGM2FLT3TUBB4A | |
| SCHEMBL276805 | 0.88 | MDM2 (0.55) | PDGFRBMDM2TGM2FLT3TUBB4A | |
| SCHEMBL27743823 | 0.83 | MEN1 (0.72) | MEN1KMT2APDGFRBFLT3 | |
| SCHEMBL13595188 | 0.83 | MEN1 (0.64) | MEN1KMT2AMDM2TUBB4ATUBB | |
| SCHEMBL275836 | 0.81 | MDM2 (0.55) | MEN1KMT2AMDM2TUBB4ATUBB | |
| SCHEMBL275835 | 0.81 | MDM2 (0.55) | MEN1KMT2AMDM2TUBB4ATUBB | |
| SCHEMBL13452985 | 0.81 | MDM2 (0.53) | PDGFRBMDM2TGM2TUBB4ATUBB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996590-B1 | SPIROINDOLINONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2010-10-06 | — | — | EP | disclosed |
| EP-1996590-A1 | SPIROINDOLINONE DERIVATIVES | F. Hoffmann-la Roche AG (CH) | 2008-12-03 | — | — | EP | disclosed |
| WO-2007104664-A1 | SPIROINDOLINONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-09-20 | — | — | WO | disclosed |