Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.84 |
| ▸ | MAOA | P21397 | 1/20 | 0.84 |
| ▸ | TP53 | P04637 | 5/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 6/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3367651 | 1.00 | MAOB (0.84) | MAOBMAOATP53LMNAPOLB | |
| Sembragiline SCHEMBL3365609 | 0.91 | MAOB (1.00) | MAOBMAOATP53LMNAPOLB | |
| Sembragiline SCHEMBL2440939 | 0.91 | MAOB (1.00) | MAOBMAOATP53LMNAPOLB | |
| Sembragiline SCHEMBL2440943 | 0.91 | MAOB (1.00) | MAOBMAOATP53LMNAPOLB | |
| SCHEMBL3367888 | 0.91 | MAOB (0.82) | MAOBMAOATP53LMNAPOLB | |
| SCHEMBL3367900 | 0.91 | MAOB (0.82) | MAOBMAOATP53LMNAPOLB | |
| Sembragiline SCHEMBL29361249 | 0.91 | MAOB (1.00) | MAOBMAOATP53LMNAPOLB | |
| SCHEMBL3366532 | 0.90 | MAOA (0.81) | MAOBMAOATP53LMNAPOLB | |
| SCHEMBL3366544 | 0.90 | MAOA (0.81) | MAOBMAOATP53LMNAPOLB | |
| SCHEMBL3368619 | 0.90 | MAOA (0.84) | MAOBMAOATP53LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542970-B1 | PYRROLIDONE DERIVATIVES AS MAOB INHIBITORS | HOFFMANN LA ROCHE (CH) | 2010-06-30 | — | — | EP | claimed |