Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 9/20 | 0.50 |
| ▸ | CALML3 | P27482 | 4/20 | 0.47 |
| ▸ | MAOB | P27338 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | SDHA | P31040 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14012749 | 1.00 | MAOA (0.50) | MAOACALML3MAOBLMNAPTGS1 | |
| SCHEMBL3371860 | 0.95 | MAOA (0.44) | MAOACALML3MAOBLMNAPTGS1 | |
| SCHEMBL3366578 | 0.95 | MAOA (0.45) | MAOACALML3MAOBLMNAPTGS1 | |
| SCHEMBL13711583 | 0.94 | MAOA (0.43) | MAOACALML3MAOBLMNAPTGS1 | |
| SCHEMBL3371931 | 0.93 | MAOA (0.43) | MAOACALML3MAOBLMNAPTGS1 | |
| SCHEMBL3367996 | 0.93 | MAOB (0.48) | MAOACALML3MAOBLMNAPTGS1 | |
| SCHEMBL13334793 | 0.93 | MAOA (0.43) | MAOACALML3MAOBLMNAPTGS1 | |
| SCHEMBL3370660 | 0.93 | MAOA (0.43) | MAOACALML3MAOBLMNAPTGS1 | |
| SCHEMBL3368353 | 0.93 | MAOA (0.43) | MAOACALML3MAOBLMNAPTGS1 | |
| SCHEMBL13711618 | 0.93 | MAOB (0.48) | MAOACALML3MAOBLMNAPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1646629-B1 | CYCLOPROPYL GROUP SUBSTITUTED OXAZOLIDINONE ANTIBIOTICS AND DERIVATIVES THEREOF | MERCK SHARP & DOHME (US) | 2010-06-23 | — | — | EP | disclosed |
| US-7582659-B2 | Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereof | MERCK & CO., INC. (US) | 2009-09-01 | — | — | US | disclosed |
| US-7462633-B2 | Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereof | MERCK & CO., INC. (US) | 2008-12-09 | — | — | US | disclosed |