Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 10/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SLC9A3 | P48764 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3363668 | 0.88 | CRHR1 (0.41) | CRHR1SMN1; SMN2ALPL | |
| SCHEMBL3364041 | 0.83 | CRHR1 (0.46) | CRHR1ALDH1A1KDM4E | |
| SCHEMBL3364646 | 0.80 | CRHR1 (0.49) | CRHR1ALDH1A1KDM4ELMNA | |
| SCHEMBL8296189 | 0.79 | CRHR1 (0.44) | CRHR1ALDH1A1KDM4E | |
| SCHEMBL3366885 | 0.79 | CRHR1 (0.48) | CRHR1ALDH1A1KDM4E | |
| SCHEMBL3365289 | 0.79 | CRHR1 (0.48) | CRHR1ALDH1A1KDM4E | |
| SCHEMBL3363779 | 0.79 | CRHR1 (0.44) | CRHR1 | |
| SCHEMBL3362573 | 0.77 | CRHR1 (0.46) | CRHR1ALDH1A1KDM4E | |
| SCHEMBL3362619 | 0.75 | CRHR1 (0.46) | CRHR1ALDH1A1KDM4E | |
| SCHEMBL3364556 | 0.74 | CRHR1 (0.49) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656353-B1 | GABANERGIC MODULATORS | HOFFMANN LA ROCHE (CH) | 2010-01-27 | — | — | EP | claimed |
| US-7365211-B2 | Heterocyclic GABAA subtype selective receptor modulators | ROCHE PALO ALTO LLC (US) | 2008-04-29 | — | — | US | disclosed |