Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 9/20 | 0.52 |
| ▸ | CLK1 | P49759 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.40 |
| ▸ | USP2 | O75604 | 5/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.40 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6883128 | 0.83 | ABCG2 (0.48) | CLK4NPC1DYRK1AMEN1KMT2A | |
| SCHEMBL3368861 | 0.78 | CLK4 (0.52) | CLK4CLK1NPC1DYRK1AMEN1 | |
| SCHEMBL28233415 | 0.74 | CLK4 (0.67) | CLK4CLK1NPC1DYRK1AMEN1 | |
| SCHEMBL28294649 | 0.67 | NPC1 (0.87) | CLK4CLK1NPC1DYRK1AMEN1 | |
| SCHEMBL2666274 | 0.66 | CLK4 (0.63) | CLK4CLK1NPC1DYRK1AMEN1 | |
| SCHEMBL10505646 | 0.65 | CLK4 (0.61) | CLK4CLK1NPC1DYRK1AMEN1 | |
| SCHEMBL14679265 | 0.63 | CLK4 (1.00) | CLK4NPC1DYRK1AMEN1KMT2A | |
| SCHEMBL28135254 | 0.63 | NPC1 (0.77) | CLK4NPC1MEN1KMT2AMAPT | |
| SCHEMBL25002922 | 0.62 | KMT2A (0.56) | CLK4CLK1NPC1MEN1KMT2A | |
| SCHEMBL29961676 | 0.62 | NPC1 (0.56) | CLK4NPC1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1476435-B1 | NOVEL PYRIDIN- AND PYRIMIDIN-DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2010-06-30 | — | — | EP | disclosed |