Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 15/20 | 0.43 |
| ▸ | SGK1 | O00141 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3373065 | 0.90 | HRH3 (0.41) | HRH3SGK1KCNH2CYP2D6 | |
| SCHEMBL3369520 | 0.83 | HRH3 (0.47) | HRH3SGK1KCNH2KDM2B | |
| SCHEMBL3372217 | 0.82 | HRH3 (0.47) | HRH3SGK1KCNH2CYP2D6 | |
| SCHEMBL1038688 | 0.76 | MAPT (0.43) | HRH3SGK1CYP2D6MEN1KMT2A | |
| SCHEMBL3369564 | 0.74 | HRH3 (0.45) | HRH3KCNH2 | |
| SCHEMBL3370618 | 0.73 | HRH3 (0.38) | HRH3SGK1KCNH2 | |
| SCHEMBL3369618 | 0.73 | HRH3 (0.44) | HRH3SGK1KCNH2 | |
| SCHEMBL1040150 | 0.73 | MAPT (0.45) | HRH3SGK1MEN1KMT2A | |
| SCHEMBL3373696 | 0.69 | HRH3 (0.39) | HRH3SGK1KCNH2 | |
| SCHEMBL1202695 | 0.69 | HRH3 (0.37) | HRH3SGK1KCNH2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010052222-A1 | (DIHYDRO)NAPHTHYRIDINONE DERIVATIVES AS HISTAMINE H3 RECEPTOR ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2010-05-14 | — | — | WO | disclosed |
| WO-2010052222-A1 | (DIHYDRO)NAPHTHYRIDINONE DERIVATIVES AS HISTAMINE H3 RECEPTOR ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2010-05-14 | — | — | WO | disclosed |