Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.44 |
| ▸ | KHK | P50053 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.37 |
| ▸ | SGK1 | O00141 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3369520 | 0.89 | HRH3 (0.47) | HRH3KCNH2SGK1 | |
| SCHEMBL3373065 | 0.84 | HRH3 (0.41) | HRH3KCNH2SGK1 | |
| SCHEMBL18669614 | 0.79 | KHK (0.47) | KHK | |
| SCHEMBL3369567 | 0.78 | HRH3 (0.49) | HRH3KCNH2 | |
| SCHEMBL5255836 | 0.73 | KHK (0.41) | HRH3KHKKCNH2 | |
| SCHEMBL3369084 | 0.73 | HRH3 (0.43) | HRH3KCNH2SGK1 | |
| SCHEMBL3369868 | 0.72 | HRH3 (0.45) | HRH3KCNH2 | |
| SCHEMBL4229745 | 0.72 | HRH3 (0.60) | HRH3KCNH2 | |
| SCHEMBL3290404 | 0.71 | NSD2 (0.41) | HRH3KHKKCNH2 | |
| SCHEMBL5208026 | 0.70 | HRH3 (0.40) | HRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010052222-A1 | (DIHYDRO)NAPHTHYRIDINONE DERIVATIVES AS HISTAMINE H3 RECEPTOR ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2010-05-14 | — | — | WO | disclosed |
| WO-2010052222-A1 | (DIHYDRO)NAPHTHYRIDINONE DERIVATIVES AS HISTAMINE H3 RECEPTOR ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2010-05-14 | — | — | WO | disclosed |