Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.52 |
| ▸ | MEN1 | O00255 | 6/20 | 0.52 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31619838 | 1.00 | MAPT (0.60) | MAPTALDH1A1MAPK1KMT2AMEN1 | |
| SCHEMBL3369857 | 1.00 | MAPT (0.60) | MAPTALDH1A1MAPK1KMT2AMEN1 | |
| SCHEMBL23369357 | 0.91 | PDE4A (0.56) | MAPTALDH1A1MAPK1KMT2AMEN1 | |
| SCHEMBL7953943 | 0.76 | MAPT (0.50) | MAPTALDH1A1MAPK1KMT2AMEN1 | |
| SCHEMBL7953939 | 0.76 | MAPT (0.50) | MAPTALDH1A1MAPK1KMT2AMEN1 | |
| SCHEMBL3370337 | 0.75 | ALDH1A1 (0.56) | MAPTALDH1A1MAPK1KMT2AACHE | |
| SCHEMBL3370335 | 0.75 | ALDH1A1 (0.56) | MAPTALDH1A1MAPK1KMT2AACHE | |
| SCHEMBL6476988 | 0.75 | KMT2A (0.68) | MAPTALDH1A1MAPK1KMT2AMEN1 | |
| SCHEMBL6476999 | 0.75 | KMT2A (0.68) | MAPTALDH1A1MAPK1KMT2AMEN1 | |
| SCHEMBL6476994 | 0.75 | KMT2A (0.68) | MAPTALDH1A1MAPK1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641792-B1 | PYRROLODIHYDROISOQUINOLINES AS PDE10 INHIBITORS | NYCOMED GMBH (DE) | 2010-08-25 | — | — | EP | disclosed |
| EP-1641457-B1 | PYRROLO-DIHYDROISOQUINOLINE DERIVATIVES AS PDE10 INHIBITORS | NYCOMED GMBH (DE) | 2009-08-05 | — | — | EP | disclosed |
| US-20070105840-A1 | Pyrrolo-dihydroisoquinoline derivatives as pde10 inhibitors | ALTANA PHARMA AG (DE) | 2007-05-10 | — | — | US | disclosed |
| US-20060148840-A1 | Pyrrolodihydroisoquinolines as pde10 inhibitors | ALTANA PHARMA AG (DE) | 2006-07-06 | — | — | US | disclosed |
| EP-1641457-A1 | PYRROLO-DIHYDROISOQUINOLINE DERIVATIVES AS PDE10 INHIBITORS | ALTANA Pharma AG (DE) | 2006-04-05 | — | — | EP | disclosed |
| EP-1641792-A1 | PYRROLODIHYDROISOQUINOLINES AS PDE10 INHIBITORS | ALTANA Pharma AG (DE) | 2006-04-05 | — | — | EP | disclosed |
| WO-2005002579-A1 | PYRROLO-DIHYDROISOQUINOLINE DERIVATIVES AS PDE10 INHIBITORS | ALTANA PHARMA AG (DE) | 2005-01-13 | — | — | WO | disclosed |
| WO-2005003129-A1 | PYRROLODIHYDROISOQUINOLINES AS PDE10 INHIBITORS | ALTANA PHARMA AG (DE) | 2005-01-13 | — | — | WO | disclosed |
| EP-1129076-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES AS LHRH ANTAGONISTS | ABBOTT LABORATORIES (US) | 2001-09-05 | — | — | EP | disclosed |
| WO-2000029380-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES AS LHRH ANTAGONISTS | ABBOTT LABORATORIES (US) | 2000-05-25 | — | — | WO | disclosed |
| US-5981521-A | USEFUL FOR TREATING VARIOUS HORMONE DEPENDENT DISEASES, INCLUDING PROSTATE CANCER, ENDOMETRIOSIS, UTERINE FIBROIDS, PRECOCIOUS PUBERTY, BENIGN PROSTATE HYPERTROPY AND IN VITRO FERTILIZATION | ABBOTT LABORATORIES (US) | 1999-11-09 | — | — | US | disclosed |
| US-4598148-A | HYPOTENSIVE AGENTS, BRONCHODIALTORS ANTIALLERGENS | HOECHST AKTIENGESELLSCHAFT (DE) | 1986-07-01 | — | — | US | disclosed |
| US-4482556-A | HYPOTENSIVE AGENTS, BRONCHODILATORS, ANTIALLERGENS | HOECHST AKTIENGESELLSCHAFT (DE) | 1984-11-13 | — | — | US | disclosed |
| US-4163786-A | Thiazoloisoquinolines with coronary and respiratory effects | CHINOIN PHARMACEUTICAL AND CHEMICAL WORKS LTD. (HU) | 1979-08-07 | — | — | US | disclosed |
| US-3979397-A | Pharmaceutically effective novel 3,4-dihydro-1,2- and 1,3-thiozolo [4,3a] is | CHINOIN PHARMACEUTICAL AND CHEMICAL WORKS LTD. (HU) | 1976-09-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060148840-A1 | Pyrrolodihydroisoquinolines as pde10 inhibitors | PDE12, PDE3A, PDE3B | MAPT 3379/4885ALDH1A1 848/4885MAPK1 1915/4885 |
| US-20070105840-A1 | Pyrrolo-dihydroisoquinoline derivatives as pde10 inhibitors | PDE12, PDE2A, PDE5A | MAPT 1795/4885ALDH1A1 665/4885MAPK1 1254/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.