Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3370766 | 0.87 | CD274 (0.42) | NPC1HPGDLMNACYP2C9CYP2C19 | |
| SCHEMBL1378422 | 0.86 | MAPT (0.40) | L3MBTL1NPC1KMT2AMEN1HPGD | |
| SCHEMBL3368784 | 0.85 | SYK (0.36) | NPC1PKMHSD17B10 | |
| SCHEMBL3371912 | 0.82 | FYN (0.34) | NPC1PKMLMNAHTTFYN | |
| SCHEMBL3372486 | 0.82 | KDM4E (0.35) | NPC1PKMHPGDFYNHSD17B10 | |
| SCHEMBL3370431 | 0.76 | MAP3K11 (0.45) | NPC1PKMFYNBRD4 | |
| SCHEMBL1376787 | 0.73 | CD274 (0.44) | NPC1KMT2AHPGDCYP2C9CYP2C19 | |
| SCHEMBL1379796 | 0.71 | MAPK1 (0.38) | KMT2A | |
| SCHEMBL1376476 | 0.70 | MAP3K11 (0.42) | PKMKMT2AMEN1LMNAFYN | |
| SCHEMBL1378956 | 0.68 | CYP11B1 (0.47) | L3MBTL1PKMLMNACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1628957-B1 | SULFOPYRROLES | TAKEDA PHARMACEUTICAL (JP) | 2010-09-29 | — | — | EP | claimed |