Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CTSA | P10619 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | XDH | P47989 | 5/20 | 0.34 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.33 |
| ▸ | APLNR | P35414 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1379796 | 0.86 | MAPK1 (0.38) | SYKMAPK1CTSAXDHACVR1 | |
| SCHEMBL3369860 | 0.85 | L3MBTL1 (0.40) | NPC1PKMHSD17B10 | |
| SCHEMBL3371912 | 0.82 | FYN (0.34) | NPC1PKMACVR1TGFBR1 | |
| SCHEMBL3370766 | 0.81 | CD274 (0.42) | NPC1KDM4EALDH1A1 | |
| SCHEMBL3372486 | 0.80 | KDM4E (0.35) | NPC1PKMACVR1KDM4EALDH1A1 | |
| SCHEMBL3370431 | 0.76 | MAP3K11 (0.45) | NPC1PKMTGFBR1 | |
| SCHEMBL1376476 | 0.70 | MAP3K11 (0.42) | MAPK1PKMACVR1ALDH1A1HSD17B10 | |
| SCHEMBL1378956 | 0.68 | CYP11B1 (0.47) | PKMALDH1A1 | |
| SCHEMBL1376787 | 0.67 | CD274 (0.44) | NPC1KDM4EALDH1A1 | |
| SCHEMBL3367765 | 0.67 | TUBB4A (0.38) | MAPK1NPC1PKMKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1628957-B1 | SULFOPYRROLES | TAKEDA PHARMACEUTICAL (JP) | 2010-09-29 | — | — | EP | claimed |