SCHEMBL3369978

SCHEMBL3369978

Cc1ccccc1N(c1ccc(-c2ccccc2)cc1)c1cc(N(c2ccc(-c3ccccc3)cc2)c2ccccc2C)cc(N(c2ccc(-c3ccccc3)cc2)c2ccccc2C)c1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TNKS2 Q9H2K2 1/20 0.37
ALDH1A1 P00352 4/20 0.33
TAAR1 Q96RJ0 1/20 0.33
PDE10A Q9Y233 1/20 0.33
NPC1 O15118 1/20 0.33
RAB9A P51151 1/20 0.33
MAPT P10636 2/20 0.33
KDM4E B2RXH2 2/20 0.33
BRD4 O60885 1/20 0.33
HPGD P15428 1/20 0.33
USP2 O75604 1/20 0.33
CYP1A2 P05177 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2D6 P10635 1/20 0.32
CYP2C9 P11712 1/20 0.32
CYP2C19 P33261 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19393440 0.94 ALDH1A1 (0.38) ALDH1A1TAAR1MAPTKDM4EHPGD
SCHEMBL17368989 0.94 ALDH1A1 (0.38) ALDH1A1TAAR1MAPTKDM4EHPGD
SCHEMBL2887338 0.92 ALDH1A1 (0.39) ALDH1A1TAAR1MAPTKDM4EHPGD
SCHEMBL17734751 0.91 MAPT (0.33) TNKS2ALDH1A1TAAR1PDE10ANPC1
SCHEMBL17734770 0.91 MAPT (0.33) TNKS2ALDH1A1TAAR1PDE10ANPC1
SCHEMBL13929897 0.90 CYP3A4 (0.40) ALDH1A1TAAR1MAPTKDM4ECYP1A2
SCHEMBL15306327 0.90 ALDH1A1 (0.38) ALDH1A1TAAR1MAPTKDM4EHPGD
SCHEMBL73930 0.90 CYP3A4 (0.40) ALDH1A1TAAR1MAPTKDM4ECYP1A2
SCHEMBL312725 0.89 CYP3A4 (0.36) ALDH1A1NPC1RAB9AMAPTKDM4E
SCHEMBL16324036 0.89 CYP3A4 (0.43) ALDH1A1TAAR1MAPTKDM4ECYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1496044-B1 NOVEL 1,3,5-TRIS(ARYLAMINO)BENZENE BANDO CHEMICAL IND (JP) 2010-11-03 EP disclosed