Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.44 |
| ▸ | GBA1 | P04062 | 9/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | UBE2N | P61088 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3370224 | 0.82 | KDM4E (0.44) | NPC1RAB9APSMD14GBA1CA1 | |
| SCHEMBL4170909 | 0.72 | KDM4E (0.49) | CA1CA2RAPGEF4L3MBTL1KDM4E | |
| SCHEMBL28904396 | 0.72 | CA1 (0.49) | CA1CA2RAPGEF4L3MBTL1KDM4E | |
| SCHEMBL28538858 | 0.72 | CA1 (0.49) | CA1CA2RAPGEF4L3MBTL1KDM4E | |
| SCHEMBL18951969 | 0.72 | CA1 (0.49) | CA1CA2RAPGEF4L3MBTL1KDM4E | |
| SCHEMBL3367690 | 0.70 | CA1 (0.43) | CA1CA2L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL28479304 | 0.70 | CA1 (0.53) | CA1CA2RAPGEF4L3MBTL1KDM4E | |
| SCHEMBL2184458 | 0.68 | CA1 (0.43) | CA1CA2L3MBTL1KDM4EUBE2N | |
| SCHEMBL29564645 | 0.68 | CA1 (0.42) | CA1CA2RAPGEF4L3MBTL1KDM4E | |
| SCHEMBL28649703 | 0.67 | CA1 (0.44) | CA1CA2RAPGEF4L3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1628957-B1 | SULFOPYRROLES | TAKEDA PHARMACEUTICAL (JP) | 2010-09-29 | — | — | EP | disclosed |
| EP-1628957-A1 | SULFOPYRROLES | Takeda Pharmaceutical Company Limited (JP) | 2006-03-01 | — | — | EP | disclosed |
| WO-2004103968-A1 | SULFOPYRROLES | APONETICS AG (CH) | 2004-12-02 | — | — | WO | disclosed |