Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 11/20 | 0.44 |
| ▸ | FPR2 | P25090 | 3/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | SCN4A | P35499 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1385459 | 0.68 | BACE1 (0.46) | SCN9AMGLLBACE1SCN4A | |
| SCHEMBL1384064 | 0.67 | SCN4A (0.45) | SCN9AFPR2MGLLBACE1SCN4A | |
| SCHEMBL4993105 | 0.66 | SCN4A (0.52) | SCN9AFPR2MGLLBACE1SCN4A | |
| Hydrochloric Acid SCHEMBL3645077 | 0.65 | HPGD (0.51) | HRH3 | |
| SCHEMBL3366604 | 0.64 | POLB (0.45) | SCN9AHRH3 | |
| SCHEMBL3368671 | 0.64 | TSHR (0.46) | — | |
| SCHEMBL1386652 | 0.63 | BACE1 (0.48) | SCN9AFPR2BACE1SCN4A | |
| SCHEMBL31132473 | 0.63 | HRH3 (0.41) | SCN9AHRH3 | |
| SCHEMBL19597620 | 0.63 | LTA4H (0.72) | SCN9AHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5571293 | 0.62 | SCN4A (0.41) | SCN9AMGLLBACE1SCN4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2266960-B1 | Aryl-substituted pyrazoles, imidazoles, oxazoles, thiazoles and pyrroles as anticonvulsants | EURO CELTIQUE SA (LU) | 2014-01-22 | — | — | EP | disclosed |
| EP-2266960-A2 | Aryl-substituted pyrazoles, imidazoles, oxazoles, thiazoles and pyrroles as anticonvulsants | EURO-CELTIQUE S.A. (LU) | 2010-12-29 | — | — | EP | disclosed |
| EP-1173169-B1 | ARYL SUBSTITUTED PYRAZOLES, IMIDAZOLES, OXAZOLES, THIAZOLES AND PYRROLES, AND THE USE THEREOF | EURO CELTIQUE SA (LU) | 2010-05-12 | — | — | EP | disclosed |