Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 19/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.43 |
| ▸ | HTR2B | P41595 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2937901 | 0.90 | REN (0.53) | RENHTR1AADRA1DHTR2AADRA1A | |
| SCHEMBL3375214 | 0.88 | REN (0.54) | RENHTR1AADRA1DHTR2AADRA1A | |
| SCHEMBL3372629 | 0.87 | REN (0.43) | RENHTR1AADRA1DHTR2AADRA1A | |
| SCHEMBL2940973 | 0.86 | REN (0.50) | RENHTR1AADRA1DHTR2AADRA1A | |
| SCHEMBL2930880 | 0.84 | REN (0.53) | RENHTR1AADRA1DHTR2AADRA1A | |
| SCHEMBL13104888 | 0.80 | REN (0.53) | RENHTR1AADRA1DHTR2AADRA1A | |
| SCHEMBL2937800 | 0.80 | REN (0.50) | RENHTR1AADRA1DHTR2AADRA1A | |
| SCHEMBL8263148 | 0.78 | REN (0.67) | RENHTR1AADRA1DHTR2AADRA1A | |
| SCHEMBL8259940 | 0.77 | REN (0.58) | RENHTR1AADRA1DHTR2AADRA1A | |
| SCHEMBL2935467 | 0.77 | REN (0.51) | RENHTR1AADRA1DHTR2AADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863477-B1 | 3,4-SUBSTITUTED PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF HYPERTENSION | NOVARTIS AG (CH) | 2010-11-03 | — | — | EP | claimed |