Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.41 |
| ▸ | GRM5 | P41594 | 5/20 | 0.37 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3398980 | 1.00 | HRH3 (0.41) | HRH3GRM5MAOAGABRG2GABRB3 | |
| SCHEMBL3370842 | 0.98 | HRH3 (0.41) | HRH3MAOAGABRG2GABRB3GABRA5 | |
| SCHEMBL3400879 | 0.98 | HRH3 (0.41) | HRH3MAOAGABRG2GABRB3GABRA5 | |
| SCHEMBL3399689 | 0.94 | HRH3 (0.43) | HRH3GRM5KCNH2 | |
| SCHEMBL3402918 | 0.93 | HRH3 (0.42) | HRH3GRM5KCNH2 | |
| SCHEMBL3372589 | 0.92 | HRH3 (0.43) | HRH3KCNH2 | |
| SCHEMBL3397891 | 0.85 | PRMT5 (0.44) | GRM5MAOAGABRG2GABRB3GABRA5 | |
| SCHEMBL3399164 | 0.84 | GABRG2 (0.40) | HRH3MAOAGABRG2GABRB3GABRA5 | |
| SCHEMBL3402822 | 0.81 | GRM5 (0.46) | HRH3GRM5GABRG2GABRB3GABRA5 | |
| SCHEMBL3401992 | 0.81 | HRH3 (0.41) | HRH3MAOAKCNH2MAOBPRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010052222-A1 | (DIHYDRO)NAPHTHYRIDINONE DERIVATIVES AS HISTAMINE H3 RECEPTOR ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2010-05-14 | — | — | WO | disclosed |
| WO-2010052222-A1 | (DIHYDRO)NAPHTHYRIDINONE DERIVATIVES AS HISTAMINE H3 RECEPTOR ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2010-05-14 | — | — | WO | disclosed |