Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALPG | P10696 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | CASR | P41180 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | BUB1 | O43683 | 1/20 | 0.34 |
| ▸ | KARS1 | Q15046 | 4/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14234645 | 0.77 | MEN1 (0.65) | MEN1RAB9AKMT2AASIC3CNR1 | |
| SCHEMBL14234652 | 0.73 | MEN1 (0.60) | MEN1RAB9AKMT2AASIC3CNR1 | |
| SCHEMBL21390796 | 0.72 | MAPT (0.69) | MEN1RAB9AKMT2AASIC3CNR1 | |
| SCHEMBL12915403 | 0.67 | MEN1 (0.56) | MEN1RAB9AKMT2AASIC3CNR1 | |
| SCHEMBL24075103 | 0.67 | RAB9A (0.55) | MEN1RAB9AKMT2AASIC3CNR1 | |
| Biphenyl SCHEMBL27906737 | 0.67 | RAB9A (0.56) | MEN1RAB9AKMT2ANPC1KDM4E | |
| SCHEMBL24134497 | 0.67 | MEN1 (0.60) | MEN1RAB9AKMT2AASIC3CNR1 | |
| SCHEMBL5914189 | 0.67 | MEN1 (0.60) | MEN1RAB9AKMT2AASIC3CNR1 | |
| SCHEMBL16844614 | 0.66 | MEN1 (0.48) | MEN1RAB9AKMT2AASIC3CNR1 | |
| Hydrochloric Acid SCHEMBL29100611 | 0.65 | MEN1 (0.58) | MEN1RAB9AKMT2AASIC3CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1476435-A1 | NOVEL PYRIDIN- AND PYRIMIDIN-DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2004-11-17 | — | — | EP | claimed |
| WO-2003068757-A9 | NOVEL PYRIDIN- AND PYRIMIDIN-DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2004-10-07 | — | — | WO | claimed |
| WO-2003068757-A1 | NOVEL PYRIDIN- AND PYRIMIDIN-DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-08-21 | — | — | WO | claimed |
| EP-1476435-B1 | NOVEL PYRIDIN- AND PYRIMIDIN-DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2010-06-30 | — | — | EP | disclosed |