Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.65 |
| ▸ | RAB9A | P51151 | 8/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | AHR | P35869 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3368257 | 0.99 | NPC1 (0.64) | NPC1RAB9ACYP2C9NR4A2MAPT | |
| SCHEMBL3371374 | 0.90 | NPC1 (0.62) | NPC1RAB9ACYP2C9NR4A2MAPT | |
| SCHEMBL3367363 | 0.87 | NPC1 (0.65) | NPC1RAB9ACYP2C9NR4A2MAPT | |
| SCHEMBL3367853 | 0.87 | CYP2C9 (0.67) | NPC1RAB9ACYP2C9NR4A2MAPT | |
| SCHEMBL3365483 | 0.85 | NPC1 (0.67) | NPC1RAB9ACYP2C9NR4A2MAPT | |
| SCHEMBL3368461 | 0.85 | NPC1 (0.70) | NPC1RAB9ACYP2C9NR4A2MAPT | |
| SCHEMBL2485532 | 0.84 | RAB9A (0.68) | NPC1RAB9ACYP2C9NR4A2MAPT | |
| SCHEMBL3370912 | 0.84 | NR4A2 (0.63) | NPC1RAB9ACYP2C9NR4A2EGLN1 | |
| SCHEMBL3772096 | 0.84 | NPC1 (0.61) | NPC1RAB9ACYP2C9NR4A2MAPT | |
| SCHEMBL3367654 | 0.82 | RAB9A (0.70) | NPC1RAB9ACYP2C9NR4A2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041133-B1 | DERIVATIVES OF IMIDAZO [1,2-A]PYRIDINE-2-CARBOXAMIDES, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | SANOFI AVENTIS (FR) | 2010-10-13 | — | — | EP | claimed |
| EP-2041133-B1 | DERIVATIVES OF IMIDAZO [1,2-A]PYRIDINE-2-CARBOXAMIDES, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | SANOFI AVENTIS (FR) | 2010-10-13 | — | — | EP | disclosed |