Styrene

Styrene

SCHEMBL3372012

C=Cc1ccccc1.O=C1C=CC(=O)O1.[Mg+2].[OH-].[OH-]

nearest known ligand 0.56

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ATP4AATP4BGABBR1GABBR2HMGCR

The experimentally established mechanism targets of Styrene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.56
TSHR P16473 1/20 0.56
HPGD P15428 3/20 0.36
TDP1 Q9NUW8 3/20 0.36
KDM4E B2RXH2 2/20 0.36
L3MBTL1 Q9Y468 2/20 0.36
CYP2A6 P11509 1/20 0.34
MAPT P10636 2/20 0.33
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
STK17B O94768 1/20 0.33
JAK2 O60674 1/20 0.33
LMNA P02545 1/20 0.33
HTT P42858 1/20 0.33
RAB9A P51151 1/20 0.33
NFKB1 P19838 1/20 0.33
NFKB2 Q00653 1/20 0.33
RELA Q04206 1/20 0.33
CMA1 P23946 1/20 0.32
TP53 P04637 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Styrene SCHEMBL10541015 0.96 ALDH1A1 (0.61) ALDH1A1TSHRHPGDTDP1KDM4E
Styrene SCHEMBL28478709 0.96 ALDH1A1 (0.61) ALDH1A1TSHRHPGDTDP1KDM4E
Styrene SCHEMBL16058 0.96 ALDH1A1 (0.61) ALDH1A1TSHRHPGDTDP1KDM4E
Styrene SCHEMBL28391640 0.94 ALDH1A1 (0.58) ALDH1A1TSHRHPGDTDP1KDM4E
Styrene SCHEMBL22656704 0.94 ALDH1A1 (0.58) ALDH1A1TSHRHPGDTDP1KDM4E
Styrene SCHEMBL3425964 0.94 ALDH1A1 (0.58) ALDH1A1TSHRHPGDTDP1KDM4E
Styrene SCHEMBL1092150 0.94 ALDH1A1 (0.58) ALDH1A1TSHRHPGDTDP1KDM4E
Styrene SCHEMBL1802309 0.92 ALDH1A1 (0.56) ALDH1A1TSHRHPGDTDP1KDM4E
Styrene SCHEMBL9602112 0.92 ALDH1A1 (0.56) ALDH1A1TSHRHPGDTDP1KDM4E
Styrene SCHEMBL27607844 0.90 ALDH1A1 (0.54) ALDH1A1TSHRHPGDTDP1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100137535-A1 POLYSTYRENE-MALEIC ANHYDRIDE/MAGNESIUM HYDROXIDE COMPOSITE PARTICLES AND METHODS FOR PREPARING THE SAME YAZAKI CORPORATION (JP) 2010-06-03 US claimed
CN-101558087-A Polystyrene-maleic anhydride/magnesium hydroxide composite particles and methods for preparing the same YAZAKI CORP (JP) 2009-10-14 CN claimed
EP-2078043-A1 POLYSTYRENE-MALEIC ANHYDRIDE/MAGNESIUM HYDROXIDE COMPOSITE PARTICLES AND METHODS FOR PREPARING THE SAME YAZAKI CORPORATION (JP) 2009-07-15 EP claimed
WO-2008054021-A1 POLYSTYRENE-MALEIC ANHYDRIDE/MAGNESIUM HYDROXIDE COMPOSITE PARTICLES AND METHODS FOR PREPARING THE SAME YAZAKI CORPORATION (JP) 2008-05-08 WO claimed
US-20100137535-A1 POLYSTYRENE-MALEIC ANHYDRIDE/MAGNESIUM HYDROXIDE COMPOSITE PARTICLES AND METHODS FOR PREPARING THE SAME YAZAKI CORPORATION (JP) 2010-06-03 US disclosed
US-20100137535-A1 POLYSTYRENE-MALEIC ANHYDRIDE/MAGNESIUM HYDROXIDE COMPOSITE PARTICLES AND METHODS FOR PREPARING THE SAME YAZAKI CORPORATION (JP) 2010-06-03 US disclosed
CN-101558087-A Polystyrene-maleic anhydride/magnesium hydroxide composite particles and methods for preparing the same YAZAKI CORP (JP) 2009-10-14 CN disclosed
CN-101558087-A Polystyrene-maleic anhydride/magnesium hydroxide composite particles and methods for preparing the same YAZAKI CORP (JP) 2009-10-14 CN disclosed
EP-2078043-A1 POLYSTYRENE-MALEIC ANHYDRIDE/MAGNESIUM HYDROXIDE COMPOSITE PARTICLES AND METHODS FOR PREPARING THE SAME YAZAKI CORPORATION (JP) 2009-07-15 EP disclosed
EP-2078043-A1 POLYSTYRENE-MALEIC ANHYDRIDE/MAGNESIUM HYDROXIDE COMPOSITE PARTICLES AND METHODS FOR PREPARING THE SAME YAZAKI CORPORATION (JP) 2009-07-15 EP disclosed
JP-2008138161-A POLYSTYRENE-MALEIC ANHYDRIDE/MAGNESIUM HYDROXIDE COMPOSITE PARTICLES AND METHODS FOR PREPARING THE SAME YAZAKI CORP 2008-06-19 JP disclosed
WO-2008054021-A1 POLYSTYRENE-MALEIC ANHYDRIDE/MAGNESIUM HYDROXIDE COMPOSITE PARTICLES AND METHODS FOR PREPARING THE SAME YAZAKI CORPORATION (JP) 2008-05-08 WO disclosed
WO-2008054021-A1 POLYSTYRENE-MALEIC ANHYDRIDE/MAGNESIUM HYDROXIDE COMPOSITE PARTICLES AND METHODS FOR PREPARING THE SAME YAZAKI CORPORATION (JP) 2008-05-08 WO disclosed