Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 8/20 | 0.56 |
| ▸ | MAOB | P27338 | 4/20 | 0.53 |
| ▸ | CALML3 | P27482 | 4/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.53 |
| ▸ | SDHA | P31040 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13711498 | 1.00 | MAOA (0.56) | MAOAMAOBCALML3PTGS1SDHA | |
| SCHEMBL3370872 | 0.93 | MAOA (0.55) | MAOAMAOBCALML3PTGS1SDHA | |
| SCHEMBL14012431 | 0.93 | MAOA (0.55) | MAOAMAOBCALML3PTGS1SDHA | |
| SCHEMBL3367078 | 0.93 | MAOA (0.56) | MAOAMAOBCALML3PTGS1SDHA | |
| SCHEMBL13711601 | 0.93 | MAOA (0.56) | MAOAMAOBCALML3PTGS1SDHA | |
| SCHEMBL13711614 | 0.93 | MAOA (0.47) | MAOAMAOBCALML3PTGS1SDHA | |
| SCHEMBL3368656 | 0.93 | MAOA (0.47) | MAOAMAOBCALML3PTGS1SDHA | |
| Hydrochloric Acid SCHEMBL3368923 | 0.93 | MAOA (0.54) | MAOAMAOBCALML3PTGS1SDHA | |
| SCHEMBL13335006 | 0.92 | MAOA (0.56) | MAOAMAOBCALML3PTGS1SDHA | |
| SCHEMBL13335261 | 0.92 | MAOA (0.49) | MAOAMAOBCALML3PTGS1SDHA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1646629-B1 | CYCLOPROPYL GROUP SUBSTITUTED OXAZOLIDINONE ANTIBIOTICS AND DERIVATIVES THEREOF | MERCK SHARP & DOHME (US) | 2010-06-23 | — | — | EP | disclosed |
| US-7582659-B2 | Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereof | MERCK & CO., INC. (US) | 2009-09-01 | — | — | US | disclosed |
| US-7462633-B2 | Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereof | MERCK & CO., INC. (US) | 2008-12-09 | — | — | US | disclosed |