Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 19/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3406800 | 0.90 | REN (0.40) | RENHTR1AADRA1DHTR2AADRA1A | |
| SCHEMBL3406532 | 0.89 | REN (0.41) | RENHTR1AADRA1DHTR2AADRA1A | |
| SCHEMBL2929798 | 0.81 | REN (0.48) | RENHTR1AADRA1DHTR2AADRA1A | |
| SCHEMBL2929797 | 0.81 | REN (0.48) | RENHTR1AADRA1DHTR2AADRA1A | |
| SCHEMBL3373431 | 0.81 | REN (0.39) | RENHTR1AADRA1DHTR2AADRA1A | |
| SCHEMBL3372260 | 0.80 | REN (0.64) | RENHTR1AADRA1DHTR2AADRA1A | |
| SCHEMBL3372059 | 0.80 | REN (0.38) | RENHTR1AADRA1DHTR2AADRA1A | |
| SCHEMBL8263148 | 0.79 | REN (0.67) | RENHTR1AADRA1DHTR2AADRA1A | |
| SCHEMBL3370811 | 0.79 | REN (0.37) | RENHTR1AADRA1DHTR2AADRA1A | |
| SCHEMBL3372333 | 0.78 | REN (0.40) | RENHTR1AADRA1DHTR2AADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863477-B1 | 3,4-SUBSTITUTED PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF HYPERTENSION | NOVARTIS AG (CH) | 2010-11-03 | — | — | EP | disclosed |