Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 20/20 | 0.58 |
| ▸ | HTR1A | P08908 | 2/20 | 0.57 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.57 |
| ▸ | HTR2A | P28223 | 2/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.57 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.57 |
| ▸ | HTR2B | P41595 | 2/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3372881 | 1.00 | REN (0.58) | RENHTR1AADRA1DHTR2AADRA1A | |
| SCHEMBL3372085 | 0.92 | REN (0.69) | RENHTR1AADRA1DHTR2AADRA1A | |
| SCHEMBL3372081 | 0.92 | REN (0.69) | RENHTR1AADRA1DHTR2AADRA1A | |
| SCHEMBL3372200 | 0.91 | REN (0.57) | RENHTR1AADRA1DHTR2AADRA1A | |
| SCHEMBL3375951 | 0.90 | REN (0.60) | RENHTR1AADRA1DHTR2AADRA1A | |
| SCHEMBL3375945 | 0.90 | REN (0.60) | RENHTR1AADRA1DHTR2AADRA1A | |
| SCHEMBL3370375 | 0.86 | REN (0.54) | RENHTR1AADRA1DHTR2AADRA1A | |
| SCHEMBL3373466 | 0.86 | REN (0.54) | RENHTR1AADRA1DHTR2AADRA1A | |
| SCHEMBL3373350 | 0.86 | REN (0.54) | RENHTR1AADRA1DHTR2AADRA1A | |
| SCHEMBL3370119 | 0.85 | REN (0.60) | RENHTR1AADRA1DHTR2AADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863477-B1 | 3,4-SUBSTITUTED PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF HYPERTENSION | NOVARTIS AG (CH) | 2010-11-03 | — | — | EP | claimed |