Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3371464 | 0.88 | KDM4E (0.34) | MAPTALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL3371468 | 0.88 | KDM4E (0.34) | MAPTALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL3375305 | 0.82 | MAPT (0.44) | MAPTALDH1A1HPGDSMN1; SMN2MEN1 | |
| SCHEMBL3372661 | 0.82 | MAPT (0.44) | MAPTALDH1A1HPGDSMN1; SMN2MEN1 | |
| SCHEMBL14337697 | 0.81 | MKNK2 (0.35) | MAPTALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL3375886 | 0.81 | MKNK2 (0.35) | MAPTALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL3375625 | 0.81 | MKNK2 (0.35) | MAPTALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL3370330 | 0.80 | ALDH1A1 (0.34) | MAPTALDH1A1HPGDSMN1; SMN2MEN1 | |
| SCHEMBL3370325 | 0.80 | ALDH1A1 (0.34) | MAPTALDH1A1HPGDSMN1; SMN2MEN1 | |
| SCHEMBL3374050 | 0.79 | ALDH1A1 (0.36) | MAPTALDH1A1HPGDSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869036-B1 | SUBSTITUTED 1,5-NAPHTHYRIDINE AZOLIDINONES AS CDK INHIBITORS | HOFFMANN LA ROCHE (CH) | 2010-11-03 | — | — | EP | claimed |