Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT2 | P31751 | 6/20 | 0.64 |
| ▸ | AKT1 | P31749 | 1/20 | 0.64 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
| ▸ | CLK1 | P49759 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.45 |
| ▸ | CCNC | P24863 | 2/20 | 0.44 |
| ▸ | CDK8 | P49336 | 2/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.43 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15689115 | 0.85 | AKT2 (0.76) | AKT2AKT1ROCK2 | |
| SCHEMBL16432987 | 0.85 | AKT2 (0.76) | AKT2AKT1ROCK2 | |
| SCHEMBL3740850 | 0.82 | AKT2 (0.70) | AKT2AKT1CHEK1MAPK1LMNA | |
| Hydrochloric Acid SCHEMBL28973063 | 0.79 | AKT2 (0.67) | AKT2AKT1CHEK1MAPK1LMNA | |
| SCHEMBL82741 | 0.78 | AKT2 (1.00) | AKT2AKT1CHEK1IDO1CLK1 | |
| Benzene SCHEMBL28198087 | 0.78 | AKT2 (1.00) | AKT2AKT1CHEK1IDO1CLK1 | |
| SCHEMBL6484211 | 0.77 | AKT2 (0.54) | AKT2AKT1CHEK1MAPK1MAPT | |
| SCHEMBL6196346 | 0.77 | — | — | |
| SCHEMBL2306002 | 0.77 | AKT1 (0.48) | AKT2AKT1CHEK1MAPK1MAPT | |
| SCHEMBL16872766 | 0.76 | AKT2 (0.95) | AKT2AKT1CHEK1CLK1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 116 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119371401-B | 4- (1H-pyrazol-4-yl) pyridine derivative targeting gram-negative bacterial lipoprotein transport pathway, composition and application thereof | 四川大学 | 2025-03-25 | — | — | CN | claimed |
| EP-3814360-B1 | HETEROARYL COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE | PTC THERAPEUTICS INC (US) | 2024-10-02 | — | — | EP | claimed |
| CN-118374005-A | Zinc coordination polymer for photocatalytic degradation of antibiotics and preparation method thereof | 平顶山学院 | 2024-07-23 | — | — | CN | claimed |
| CN-118146523-A | Cadmium coordination polymer and preparation method and application thereof | 平顶山学院 | 2024-06-07 | — | — | CN | claimed |
| CN-117903446-A | Cu-MOFs crystal material and preparation method and application thereof | 五邑大学 | 2024-04-19 | — | — | CN | claimed |
| CN-109590023-B | Palladium-containing supramolecular catalyst based on flexible imidazole ligand as well as preparation and application thereof | 北京工业大学 | 2021-10-01 | — | — | CN | claimed |
| US-20140301999-A1 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATORY, CARDIOVASCULAR AND CNS DISORDERS | DECODE GENETICS EHF (IS) | 2014-10-09 | — | — | US | claimed |
| EP-2674417-A2 | Biaryl PDE4 inhibitors for treating inflammation | Decode Genetics EHF (IS) | 2013-12-18 | — | — | EP | claimed |
| CN-102026970-B | Biaryl PDE4 inhibitors for the treatment of pulmonary and cardiovascular disorders | DECODE GENETICS EHF | 2013-07-31 | — | — | CN | claimed |
| US-20120213758-A1 | BIARYL PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS | DeCODE Genetics enf (IS) | 2012-08-23 | — | — | US | claimed |
| US-20120183522-A1 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATORY, CARDIOVASCULAR AND CNS DISORDERS | DECODE GENETICS EHF (IS) | 2012-07-19 | — | — | US | claimed |
| CN-102089279-A | Biaryl PDE4 inhibitors for treating inflammation | DECODE GENETICS EHF | 2011-06-08 | — | — | CN | claimed |
| CN-102026970-A | Biaryl PDE4 inhibitors for the treatment of pulmonary and cardiovascular disorders | DECODE GENETICS EHF | 2011-04-20 | — | — | CN | claimed |
| EP-2222639-A1 | BIARYL PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS | Decode Genetics EHF (IS) | 2010-09-01 | — | — | EP | claimed |
| EP-2222638-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | Decode Genetics EHF (IS) | 2010-09-01 | — | — | EP | claimed |
| US-20090324569-A1 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATORY, CARDIOVASCULAR AND CNS DISORDERS | DECODE GENETICS EHF (IS) | 2009-12-31 | — | — | US | claimed |
| US-20090136473-A1 | BIARYL PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | US | claimed |
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | claimed |
| WO-2009067621-A1 | BIARYL PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | claimed |
| WO-2003051906-A2 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-06-26 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090136473-A1 | BIARYL PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS | PDE4A, PDE4B, PDE3B | AKT2 1263/4885AKT1 1142/4885CHEK1 4073/4885 |
| US-20120183522-A1 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATORY, CARDIOVASCULAR AND CNS DISORDERS | PDE4A, PDE4B, PDE3B | AKT2 916/4885AKT1 678/4885CHEK1 4471/4885 |
| US-20140301999-A1 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATORY, CARDIOVASCULAR AND CNS DISORDERS | PDE4A, PDE4B, PDE3B | AKT2 916/4885AKT1 678/4885CHEK1 4471/4885 |
| US-20120213758-A1 | BIARYL PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS | PDE4A, PDE4B, PDE3B | AKT2 1263/4885AKT1 1142/4885CHEK1 4073/4885 |
| US-20090324569-A1 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATORY, CARDIOVASCULAR AND CNS DISORDERS | PDE4A, PDE4B, PDE3B | AKT2 916/4885AKT1 678/4885CHEK1 4471/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.