Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GNE | Q9Y223 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14671991 | 0.86 | KDM4E (0.65) | KDM4EALOX15TSHRACMSDTDP1 | |
| SCHEMBL2224487 | 0.86 | KDM4E (0.65) | KDM4EALOX15TSHRACMSDTDP1 | |
| SCHEMBL2224481 | 0.86 | KDM4E (0.65) | KDM4EALOX15TSHRACMSDTDP1 | |
| Pyridine Dicarboxamide SCHEMBL29587789 | 0.85 | TSHR (0.59) | PIM1KDM4EALOX15TSHRACMSD | |
| Pyridine Dicarboxamide SCHEMBL229425 | 0.85 | TSHR (0.59) | PIM1KDM4EALOX15TSHRACMSD | |
| Pyridine Dicarboxamide SCHEMBL29501171 | 0.83 | TSHR (0.56) | PIM1KDM4EALOX15TSHRACMSD | |
| Pyridine Dicarboxamide SCHEMBL29031925 | 0.83 | TSHR (0.56) | PIM1KDM4EALOX15TSHRACMSD | |
| Pyridine Dicarboxamide SCHEMBL15347496 | 0.83 | TSHR (0.56) | PIM1KDM4EALOX15TSHRACMSD | |
| Pyridine Dicarboxamide SCHEMBL38659131 | 0.83 | TSHR (0.56) | PIM1KDM4EALOX15TSHRACMSD | |
| SCHEMBL20963454 | 0.80 | MAPT (0.50) | KDM4ETSHRCYP1A2ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1220838-B1 | 1-AZIRIDINO-1-HYDROXYIMINOMETHYL-DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICAMENTS CONTAINING SAID COMPOUNDS | KALVINS PROF DR IVARS (LV) | 2010-11-03 | — | — | EP | disclosed |
| US-7078418-B1 | 1-aziridino-1-hydroxyiminomethyl-derivates, method for the production thereof and medicaments containing said compounds | Kalvins, Ivars (LV) | 2006-07-18 | — | — | US | disclosed |