Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK11 | Q15759 | 8/20 | 0.59 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.38 |
| ▸ | LDHA | P00338 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PLAT | P00750 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isopropylamine SCHEMBL4890140 | 0.94 | MAPK11 (0.53) | MAPK11MAPK14KCNH2MAPK13RAF1 | |
| SCHEMBL4762891 | 0.86 | MAPK11 (0.52) | MAPK11MAPK14KCNH2MAPK13RAF1 | |
| SCHEMBL4761409 | 0.86 | MAPK11 (0.52) | MAPK11MAPK14KCNH2MAPK13RAF1 | |
| SCHEMBL4865422 | 0.86 | MAPK14 (0.52) | MAPK11MAPK14KCNH2MAPK13RAF1 | |
| SCHEMBL4828451 | 0.86 | MAPK11 (0.52) | MAPK11MAPK14KCNH2MAPK13RAF1 | |
| SCHEMBL4761678 | 0.86 | MAPK14 (0.52) | MAPK11MAPK14KCNH2MAPK13RAF1 | |
| SCHEMBL4761470 | 0.85 | MAPK11 (0.52) | MAPK11MAPK14KCNH2MAPK13RAF1 | |
| SCHEMBL4761674 | 0.85 | MAPK11 (0.51) | MAPK11MAPK14KCNH2MAPK13RAF1 | |
| SCHEMBL6004425 | 0.84 | MAPK11 (0.56) | MAPK11MAPK14KCNH2MAPK9LMNA | |
| SCHEMBL4830402 | 0.84 | MAPK11 (0.50) | MAPK11MAPK14KCNH2MAPK13RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102186479-A | Aminopyrimidine inhibitors of histamine receptors for the treatment of disease | KALYPSYS INC | 2011-09-14 | — | — | CN | disclosed |
| WO-2010030757-A2 | AMINOPYRIMIDINE INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | KALYPSYS INC. (US) | 2010-03-18 | — | — | WO | disclosed |
| EP-1871770-A1 | ORTHO-TERPHENYL INHIBITORS OF P38 KINASE AND METHODS OF TREATING INFLAMMATORY DISORDERS | Kalypsys, Inc. (US) | 2008-01-02 | — | — | EP | disclosed |
| US-20060252807-A1 | Novel ortho-terphenyl inhibitors of p38 kinase and methods of treating inflammatory disorders | KALYPSYS, INC. | 2006-11-09 | — | — | US | disclosed |
| WO-2006116355-A1 | ORTHO-TERPHENYL INHIBITORS OF P38 KINASE AND METHODS OF TREATING INFLAMMATORY DISORDERS | KALYPSYS, INC. (US) | 2006-11-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060252807-A1 | Novel ortho-terphenyl inhibitors of p38 kinase and methods of treating inflammatory disorders | MAPK1, MAP3K1, MAPK4 | MAPK11 45/4885MAPK14 26/4885KCNH2 4599/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.